Non-rhinovirus enteroviruses associated with respiratory infections in Peru 2005-2010Reportar como inadecuado

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Virology Journal

, 11:169

Positive-strand RNA viruses


BackgroundEnteroviruses EVs are a common cause of respiratory tract infections and are classified into seven species EVA-D and rhinoviruses RHVs A-C with more than 200 different serotypes. Little is known about the role of non-RHV EVs in respiratory infections in South America. The aim of this study was to describe the epidemiology of non-RHV EVs detected in patients with influenza-like illness enrolled in a passive surveillance network in Peru.

MethodsThroat swabs and epidemiological data were collected from participants after obtaining verbal consent. Viral isolation was performed in cell culture and identified by immunofluorescence assay. Serotype identification of EV isolates was performed using commercial monoclonal antibodies. Identification of non-serotypeable isolations was carried out by reverse transcriptase-PCR, followed by sequencing.

ResultsBetween 2005 and 2010, 24,239 samples were analyzed, and 9,973 41.1% possessed at least one respiratory virus. EVs were found in 175 samples 0.7%. Our results revealed a clear predominance of EVB species, 90.9% 159-175. No EVDs were isolated. The mean and median ages of EV-positive subjects were 9.1 and 4.0 years, respectively, much younger than the population sampled, 17.6 and 12.0 years. Sixteen serotypes were identified, four EVA, 11 EVB, and one EVC species. The most common serotypes were coxsackievirus B1, coxsackievirus B2, coxsackievirus B5, and coxsackievirus B3.

ConclusionThis study provides data about the serotypes of EVs circulating in Peru and sets the need for further studies.

KeywordsEnterovirus Respiratory infections Peru Electronic supplementary materialThe online version of this article doi:10.1186-1743-422X-11-169 contains supplementary material, which is available to authorized users.

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Autor: Jose L Huaman - Gladys Carrion - Julia S Ampuero - Jorge Gomez - Victor Ocaña - Irmia Paz - Elizabeth Gomez - Edward Ch


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