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Health and Quality of Life Outcomes

, 12:141

First Online: 28 September 2014Received: 10 March 2014Accepted: 03 September 2014

Abstract

BackgroundThis study explores relationships between chronic inflammation and quality of life, making a case for biopsychosocial modeling of these associations. It builds on research from social and clinical disciplines connecting chronic conditions, and inflammatory conditions specifically, to reduced quality of life.

MethodsData from Wave I of the National Social Life, Health, and Aging Project are modeled using ordinal logistic and ordinary least-squares regression techniques. Inflammation is measured using C-reactive protein; quality of life is conceptualized as happiness with life overall as well as intimate relationships specifically.

ResultsFor most NSHAP participants, chronic inflammation significantly predicts lower odds of reporting high QoL on both emotional and relational measures. Social structural factors do not confound these associations. Inconsistent results for participants with very high over 6 mg-L CRP measurements suggest additional social influences.

ConclusionsFindings echo strong theoretical justification for investigating relationships between CRP and QoL in greater detail. Further research should explore possible mediation of these associations by sociomedical sequelae of chronic disease as well as social relationship dynamics. Elaboration is also needed on the mechanisms by which social disadvantage may cause chronic inflammation.

KeywordsInflammation Quality of life Health NSHAP Chronic conditions Quantitative AbbreviationsCRPC-reactive protein

NSHAPNational social life, health, and aging project

OLSOrdinary least-squares

QoLQuality of life

SEMStructural equation modeling

Electronic supplementary materialThe online version of this article doi:10.1186-s12955-014-0141-0 contains supplementary material, which is available to authorized users.

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Autor: Alexandra CH Nowakowski

Fuente: https://link.springer.com/







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