PlatinumII and palladiumII complexes with N-aminoguanidineReportar como inadecuado




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* Corresponding author 1 SEESIB - Synthèse et étude de systèmes à intêret biologique 2 Dipartimento di Chimica Strutturale e Stereochimica Inorganica 3 SSMIP - Synthèse et structure de molécules d-interet pharmacologique 4 Laboratoire de cristallochimie Bioinorganique 5 LCBPT - Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques 6 LCRB - Laboratoire de cristallographie et RMN biologiques

Abstract : N-Aminoguanidine Amgu was examined for its behaviour as a ligand for platinumII and palladiumII. Protonated AmguH+ can coordinate platinum as a monodentate ligand bound via the N4 amino group. Deprotonated, electrically neutral Amgu forms chelate complexes with both PtII and PdII; in these complexes Amgu is coordinated to the metal by the N4 amino group and the deprotonated N1 imino group, forming a five-membered ring. KPtCl3dmso reacted with Amgu·HCl to yield a chelate complex with N1 bound trans to S, suggesting that an exchange between the N1 and N4 binding sites followed the primary nucleophilic attack of N4 on platinum. Whereas reactions between K2PdCl4 and Amgu·HCl were rapid and straightforward, K2PtCl4 was easily reduced to metallic platinum by Amgu·HCl, especially in stoichiometric conditions. Solution NMR and X-ray crystallographic characterization is presented for five new complexes: trans-PtCl2AmguH-N42Cl2·21-2H2O 3, trans-PtAmgu-N1,N42NO32 4, PtClAmgu-N1,N4dmsoCl·2H2O 5, PdCl2AmguH-N1,N4 6, and trans-PdAmgu-N1,N42Cl2 7

Keywords : Platinum Palladium N ligands Coordination modes





Autor: David J Aitken - Alberto Albinati - Arnaud Gautier - Henri-Philippe Husson - Georges Morgant - Dung Nguyen-Huy - Jiri Kozelka - P

Fuente: https://hal.archives-ouvertes.fr/



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