Gluconate 5-dehydrogenase Ga5DH participates in Streptococcus suis cell divisionReportar como inadecuado

Gluconate 5-dehydrogenase Ga5DH participates in Streptococcus suis cell division - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Protein and Cell

, Volume 5, Issue 10, pp 761–769

First Online: 11 June 2014Received: 01 April 2014Accepted: 04 May 2014


Bacterial cell division is strictly regulated in the formation of equal daughter cells. This process is governed by a series of spatial and temporal regulators, and several new factors of interest to the field have recently been identified. Here, we report the requirement of gluconate 5-dehydrogenase Ga5DH in cell division of the zoonotic pathogen Streptococcus suis. Ga5DH catalyzes the reversible reduction of 5-ketogluconate to D-gluconate and was localized to the site of cell division. The deletion of Ga5DH in S. suis resulted in a plump morphology with aberrant septa joining the progeny. A significant increase was also observed in cell length. These defects were determined to be the consequence of Ga5DH deprivation in S. suis causing FtsZ delocalization. In addition, the interaction of FtsZ with Ga5DH in vitro was confirmed by protein interaction assays. These results indicate that Ga5DH may function to prevent the formation of ectopic Z rings during S. suis cell division.

KeywordsStreptococcus suis Ga5DH cell shape cell division FtsZ localization  Download fulltext PDF

Autor: Zhongyu Shi - Chunling Xuan - Huiming Han - Xia Cheng - Jundong Wang - Youjun Feng - Swaminath Srinivas - Guangwen Lu - Ge


Documentos relacionados