Interfacial Ca2 environments in nanocrystalline apatites revealed by dynamic nuclear polarization enhanced 43Ca NMR spectroscopyReportar como inadecuado




Interfacial Ca2 environments in nanocrystalline apatites revealed by dynamic nuclear polarization enhanced 43Ca NMR spectroscopy - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1 UGA - Université Grenoble Alpes 2 CEA-INAC-SPSMS - CEA-INAC-SPSMS 3 LCMCP - Laboratoire de Chimie de la Matière Condensée de Paris 4 SMiLES - Spectroscopie, Modélisation, Interfaces pour L-Environnement et la Santé LCMCP - Laboratoire de Chimie de la Matière Condensée de Paris 5 ICG ICMMM - Institut Charles Gerhardt - Institut de Chimie Moléculaire et des Matériaux de Montpellier

Abstract : The interfaces within bones, teeth and other hybrid biomaterials are of paramount importance but remain particularly difficult to characterize at the molecular level because both sensitive and selective techniques are mandatory. Here, it is demonstrated that unprecedented insights into calcium environments, for example the differentiation of surface and core species of hydroxyapatite nanoparticles, can be obtained using solid-state NMR, when combined with dynamic nuclear polarization. Although calcium represents an ideal NMR target here and de facto for a large variety of calcium-derived materials, its stable NMR-active isotope, calcium-43, is a highly unreceptive probe. Using the sensitivity gains from dynamic nuclear polarization, not only could calcium-43 NMR spectra be obtained easily, but natural isotopic abundance 2D correlation experiments could be recorded for calcium-43 in short experimental time. This opens perspectives for the detailed study of interfaces in nanostructured materials of the highest biological interest as well as calcium-based nanosystems in general.

Keywords : DNP 43Ca apatite biomaterial





Autor: Daniel Lee - César Leroy - Charlene Crevant - Laure Bonhomme-Coury - Florence Babonneau - Danielle Laurencin - Christian Bonhom

Fuente: https://hal.archives-ouvertes.fr/



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