Abdominal obesity and low physical activity are associated with insulin resistance in overweight adolescents: a cross-sectional studyReportar como inadecuado




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BMC Pediatrics

, 14:258

Nutrition, diet, physical health and endocrinology

Abstract

BackgroundPrevious studies have assessed the metabolic changes and lifestyles associated with overweight adolescents. However, these associations are unclear amongst overweight adolescents who have already developed insulin resistance. This study assessed the associations between insulin resistance and anthropometric, metabolic, inflammatory, food consumption, and physical activity variables amongst overweight adolescents.

MethodsThis cross-sectional study divided adolescents n = 120 between 10 and 18 years old into 3 groups: an overweight group with insulin resistance O + IR, an overweight group without insulin resistance O-IR, and a normal-weight control group NW. Adolescents were matched across groups based on age, sex, pubertal maturation, and socioeconomic strata. Anthropometric, biochemical, physical activity, and food consumption variables were assessed. Insulin resistance was assessed using homeostatic model assessment HOMA Calculator Version 2.2.2 from ©Diabetes Trials Unit, University of Oxford, and overweight status was assessed using body mass index according to World Health Organization 2007 references. A chi-square test was used to compare categorical variables. ANOVAs or Kruskal-Wallis tests were used for continuous variables. Multiple linear regression models were used to calculate the probability of the occurrence of insulin resistance based on the independent variables.

ResultsThe risk of insulin resistance amongst overweight adolescents increases significantly when they reach a waist circumference > p95 OR = 1.9, CIs = 1.3-2.7, p = 0.013 and watch 3 or more hours-day of television OR = 1.7, CIs = 0.98-2.8, p = 0.033. Overweight status and insulin resistance were associated with higher levels of inflammation hsCRP ≥1 mg-L and cardiovascular risk according to arterial indices. With each cm increase in waist circumference, the HOMA index increased by 0.082; with each metabolic equivalent MET unit increase in physical activity, the HOMA index decreased by 0.026.

ConclusionsSedentary behaviour and a waist circumference > p90 amongst overweight adolescents were associated with insulin resistance, lipid profile alterations, and higher inflammatory states. A screening that includes body mass index, in waist circumference, and physical activity evaluations of adolescents might enable the early detection of these alterations.

KeywordsInsulin resistance Abdominal obesity Metabolic syndrome Physical activity Adolescents AbbreviationsIRInsulin resistance

MSMetabolic syndrome

DM2Diabetes mellitus 2

hsCRPHigh-sensitivity C-reactive protein

CVDCardiovascular disease

WCWaist circumference

PAPhysical activity

BMIBody mass index

SFFsSubscapular fat folds

TFFsTriceps fat folds

TCTotal cholesterol

HDL-cHDL cholesterol

LDL-cLDL cholesterol

TGTriglycerides

AIArterial index

CICastelli index

MVPAModerate-to-vigorous physical activity

VPAVigorous physical activity

METMetabolic equivalents

%BFBody fat percentage

OROdds ratio

CIsConfidence intervals.

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Autor: Claudia-María Velásquez-Rodríguez - Marcela Velásquez-Villa - Leidy Gómez-Ocampo - Juliana Bermúdez-Cardona

Fuente: https://link.springer.com/







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