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BMC Geriatrics

, 14:110

Neurology, stroke and cognition

Abstract

BackgroundAlzheimer’s disease is characterised by a loss of cognitive function and behavioural problems as set out in the term -Behavioural and Psychological Symptoms of Dementia-. These behavioural symptoms have heavy consequences for the patients and their families.

A greater understanding of behavioural symptoms risk factors would allow better detection of those patients, a better understanding of crisis situations and better management of these patients. Some retrospective studies or simple observations suggested that personality could play a role in the occurrence of behavioural symptoms. Finally, performance in social cognition like facial recognition and perspective taking could be linked to certain personality traits and the subsequent risks of behavioural symptoms.

We propose to clarify this through a prospective, multicentre, multidisciplinary study.

Main Objective:

- To assess the effect of personality and life events on the risk of developing behavioural symptoms.

Secondary Objectives:

- To evaluate, at the time of inclusion, the connection between personality and performance in social cognition tests;

- To evaluate the correlation between performance in social cognition at inclusion and the risks of occurrence of behavioural symptoms;

- To evaluate the correlation between regional cerebral atrophy, using brain Magnetic Resonance Imaging at baseline, and the risk of behavioural symptoms.

Methods-DesignStudy type and Population: Prospective multicentre cohort study with 252 patients with Alzheimer’s disease at prodromal or mild dementia stage.

The inclusion period will be of 18 months and the patients will be followed during 18 months. The initial evaluation will include: a clinical and neuropsychological examination, collection of behavioural symptoms data Neuropsychiatric-Inventory scale and their risk factors, a personality study using both a dimensional personality traits and categorical approach, an inventory of life events, social cognition tests and an Magnetic Resonance Imaging. Patients will be followed every 6 months clinical examination and collection of behavioural symptoms data and risk factors during 18 months.

DiscussionThis study aims at better identifying the patients with Alzheimer’s disease at high risk of developing behavioural symptoms, to anticipate, detect and quickly treat these disorders and so, prevent serious consequences for the patient and his caregivers.

Trial registrationClincalTrials.gov: NCT01297140

KeywordsAlzheimer’s disease Personality Behaviour Electronic supplementary materialThe online version of this article doi:10.1186-1471-2318-14-110 contains supplementary material, which is available to authorized users.

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Autor: Isabelle Rouch - Jean-Michel Dorey - Nawèle Boublay - Marie-Anne Henaff - Florence Dibie-Racoupeau - Zaza Makaroff - Sandri

Fuente: https://link.springer.com/







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