Association between Fok I vitamin D receptor gene VDR polymorphism and impulsivity in alcohol-dependent patientsReportar como inadecuado




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Molecular Biology Reports

, Volume 41, Issue 11, pp 7223–7228

First Online: 25 July 2014Received: 01 April 2013Accepted: 10 July 2014

Abstract

Vitamin D appears to have an important role in the modulation of the central nervous system. Vitamin D exerts its biological effects through its interaction with the vitamin D receptor VDR. Located on chromosome 12 12q13.1, the VDR gene has many different polymorphisms. Some of them are known to affect the VDR function, such as FokI rs2228570, T-C single nucleotide polymorphism. We aimed to explore a potential relationship between FokI VDR polymorphism and impulsiveness in alcohol-dependent AD patients. The study population consisted of 148 patients diagnosed with alcohol dependence DSM-IV criteria and 212 healthy controls. DNA was extracted from whole blood samples using the standard procedure. Genotypes were analyzed using a real-time PCR method. We found that FokI VDR gene polymorphism was associated with impulsivity Barratt Impulsiveness Scale BIS-11 total score; P = 0.014, and with attentional impulsivity BIS-11 subscale; P = 0.002 in the male AD patients. Our results suggest that CC FokI genotype of the VDR gene is associated with a higher level of impulsivity in these patients. This finding supports the hypothesis that impulsiveness, which significantly contributes to development of alcohol dependence, has a genetic background.

KeywordsAlcohol dependence Impulsivity Vitamin D receptor gene Genetic polymorphism  Download fulltext PDF



Autor: Małgorzata Wrzosek - Andrzej Jakubczyk - Michał Wrzosek - Beata Kaleta - Jacek Łukaszkiewicz - Halina Matsumoto - Kirk B

Fuente: https://link.springer.com/







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