Opsoclonus-myoclonus syndrome associated with multiple system atrophyReport as inadecuate

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Cerebellum and Ataxias

, 1:15

First Online: 01 November 2014Received: 05 August 2014Accepted: 29 August 2014


Opsoclonus-myoclonus syndrome OMS is well known as a paraneoplastic syndrome or as a parainfectious neurologic complication. However, OMS associated with a neurodegenerative disorder has not been described previously. A 48-year-old woman had been diagnosed as multiple system atrophy-parkinsonian type MSA-P based on the findings of dopamine non-responsive parkinsonism with autonomic failure and typical findings on magnetic resonance imaging 5 years ago. She exhibited recurrent asynchronous and arrhythmic myoclonic movements of the upper limbs and abdomen with a very short duration, and involuntary eye movements, which were repetitive, rapid, random, multidirectional, conjugate saccades of irregular amplitude and frequency at rest. Based on hematological and radiological findings, the diagnosis was advanced MSA-P associated with OMS. As far as we are aware, there have not been any previous reports of such a case.

KeywordsOpsoclonus-myoclonus syndrome Multiple system atrophy Ocular symptom Cerebellar vermis Pontine reticular formation AbbreviationsMSAMultiple system atrophy

OMSOpsoclonus-myoclonus syndrome

Electronic supplementary materialThe online version of this article doi:10.1186-s40673-014-0015-6 contains supplementary material, which is available to authorized users.

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Author: Kazumasa Shindo - Akiko Onohara - Takanori Hata - Fumikazu Kobayashi - Kaori Nagasaka - Takamura Nagasaka - Yoshihisa Takiy

Source: https://link.springer.com/

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