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BMC Infectious Diseases

, 14:617

Tuberculosis and other mycobacterial diseases


BackgroundTuberculosis TB during pregnancy may lead to severe consequences affecting both mother and child. Prenatal care could be a very good opportunity for TB care, especially for women who have limited access to health services. The aim of this review was to gather and evaluate studies on TB care for pregnant women.

MethodsWe used a combination of the terms -tuberculosis- and -pregnancy-, limited to human, to search for published articles. Studies reflecting original data and focusing on TB care for pregnant women were included. All references retrieved were collected using the Reference Manager software Version 11.

ResultsThirty five studies were selected for review and their data showed that diagnosis was often delayed because TB symptoms during pregnancy were not typical. TB prophylaxis and anti-TB therapy appeared to be safe and effective for pregnant women and their babies when suitable follow up and early initiation were present, but the compliance rate to TB prophylaxis is still low due to lack of follow up and referral services. TB care practices in the reviewed studies were in line in principle with the WHO International Standards for Tuberculosis Care ISTC.

ConclusionsIntegration of TB care within prenatal care would improve TB diagnosis and treatment for pregnant women. To improve the quality of TB care, it is necessary to develop national level guidelines based on the ISTC with detailed guidelines for pregnant women.

KeywordsDelivery of health care Pregnancy Tuberculosis Women AbbreviationsAFBAcid-fast bacillus

ARDSAcute respiratory distress syndrome

DOTDirectly observed treatment

DRDrug resistant

HIVHuman immunodeficiency virus

IGRAInterferon gamma release assay

ISTCInternational standards for tuberculosis care

LTBILatent tuberculosis infection

MDR-TBMultidrug resistant tuberculosis

PTBPulmonary tuberculosis


TSTTuberculin sensitivity test

WHOWorld health organization

XDR-TBExtensively drug resistant tuberculosis

Electronic supplementary materialThe online version of this article doi:10.1186-s12879-014-0617-x contains supplementary material, which is available to authorized users.

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Autor: Hang Thanh Nguyen - Chiara Pandolfini - Peter Chiodini - Maurizio Bonati


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