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Biophysical Reviews

, Volume 6, Issue 3–4, pp 311–321

First Online: 29 November 2014Received: 25 August 2014Accepted: 13 November 2014


The recent application of molecular dynamics MD methodology to investigate the allosteric transitions of the acetylcholine receptor and its prokaryotic and eukaryotic pentameric homologs has yielded new insights into the mechanisms of signal transduction by these receptors. Combined with available data on X-ray structures, MD techniques enable description of the dynamics of the conformational change at the atomic level, intra-molecular propagation of this signal transduction mechanism as a concerted stepwise process at physiological timescales and the control of this process by allosteric modulators, thereby offering new perspectives for drug design.

KeywordsAllosteric interactions Acetylcholine receptor Molecular dynamics Conformational changes  Download fulltext PDF

Autor: Jean-Pierre Changeux



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