Enterobiasis and strongyloidiasis and associated co-infections and morbidity markers in infants, preschool- and school-aged children from rural coastal Tanzania: a cross-sectional studyReportar como inadecuado




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BMC Infectious Diseases

, 14:644

Parasitological diseases

Abstract

BackgroundThere is a paucity of data pertaining to the epidemiology and public health impact of Enterobius vermicularis and Strongyloides stercoralis infections. We aimed to determine the extent of enterobiasis, strongyloidiasis, and other helminth infections and their association with asymptomatic Plasmodium parasitaemia, anaemia, nutritional status, and blood cell counts in infants, preschool-aged PSAC, and school-aged children SAC from rural coastal Tanzania.

MethodsA total of 1,033 children were included in a cross-sectional study implemented in the Bagamoyo district in 2011-2012. Faecal samples were examined for intestinal helminth infections using a broad set of quality controlled methods. Finger-prick blood samples were subjected to filariasis and Plasmodium parasitaemia testing and full blood cell count examination. Weight, length-height, and-or mid-upper arm circumference were measured and the nutritional status determined in accordance with age.

ResultsE. vermicularis infections were found in 4.2% of infants, 16.7%, of PSAC, and 26.3% of SAC. S. stercoralis infections were detected in 5.8%, 7.5%, and 7.1% of infants, PSAC, and SAC, respectively. Multivariable regression analyses revealed higher odds of enterobiasis in children of all age-groups with a reported anthelminthic treatment history over the past six months odds ratio OR: 2.15; 95% confidence interval CI: 1.22 - 3.79 and in SAC with a higher temperature OR: 2.21; CI: 1.13 - 4.33. Strongyloidiasis was associated with eosinophilia OR: 2.04; CI: 1.20-3.48 and with Trichuris trichiura infections OR: 4.13; CI: 1.04-16.52 in children of all age-groups, and with asymptomatic Plasmodium parasitaemia OR: 13.03; CI: 1.34 - 127.23 in infants. None of the investigated helminthiases impacted significantly on the nutritional status and anaemia, but moderate asymptomatic Plasmodium parasitaemia was a strong predictor for anaemia in children aged older than two years OR: 2.69; 95% CI: 1.23 – 5.86.

ConclusionsE. vermicularis and S. stercoralis infections were moderately prevalent in children from rural coastal Tanzania. Our data can contribute to inform yet missing global burden of disease and prevalence estimates for strongyloidiasis and enterobiasis. The association between S stercoralis and asymptomatic Plasmodium parasitaemia found here warrants further comprehensive investigations.

KeywordsAsymptomatic Plasmodium parasitaemia Anaemia Anthropometric measures Co-infection Enterobius vermicularis Haematology Hookworm Soil-transmitted helminths Strongyloides stercoralis Tanzania Trichuris trichiura AbbreviationsCIConfidence interval

CRFCase report form

DALYsDisability adjusted life years

EKBBEthikkomission beider Basel

EPGEggs per gram of stool

FECFaecal egg count

HIV-AIDSHuman immunodeficiency virus-acquired immune deficiency syndrome

ICTImmunochromatic test

IHI-BRTCIfakara Health Institute-Bagamoyo Research and Training Centre

MUACMid-upper arm circumference

NIMRNational Institution for Medical Research of Tanzania

OROdds ratio

PanACEAPan African Collaboration for the Evaluation of Antituberculosis Antibiotics

PSACPreschool-aged children

SACSchool-aged children

Swiss TPHSwiss Tropical and Public Health Institute

TBTuberculosis

UNICEFUnited Nations Children-s Fund

VHCWVillage health care worker

WHOWorld Health Organization

Electronic supplementary materialThe online version of this article doi:10.1186-s12879-014-0644-7 contains supplementary material, which is available to authorized users.

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Autor: Nahya Salim - Tobias Schindler - Ummi Abdul - Julian Rothen - Blaise Genton - Omar Lweno - Alisa S Mohammed - John Masimb

Fuente: https://link.springer.com/



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