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Journal of Biological Engineering

, 8:30

Emerging biomaterials for translational medicine

Abstract

The integration of gene delivery technologies with electrospun nanofibers is a versatile strategy to increase the potential of gene therapy as a key platform technology that can be readily utilized for numerous biomedical applications, including cancer therapy, stem cell therapy, and tissue engineering. As a spatial template for gene delivery, electrospun nanofibers possess highly advantageous characteristics, such as their ease of production, their ECM-analogue nature, the broad range of choices for materials, the feasibility of producing structures with varied physical and chemical properties, and their large surface-to-volume ratios. Thus, electrospun fiber-mediated gene delivery exhibits a great capacity to modulate the spatial and temporal release kinetics of gene vectors and enhance gene delivery efficiency. This review discusses the powerful characteristics of electrospun nanofibers, which can function as spatial interfaces capable of promoting controlled and efficient gene delivery.

KeywordsGene delivery Electrospun nanofibers Controlled gene delivery Tissue engineering Sustained release AbbreviationsAAVAdeno-associated virus

AdAdenovirus

AoSMCAortic smooth muscle cell

bFGFBasic fibroblast growth factor

bFGFBasic fibroblast growth factor

BMP-2Bone morphogenetic protein-2

Cdk2Cyclin-dependent kinase 2

CMVCytomegalovirus

ECMExtracellular matrix

EEPEthyl ethylene phosphate

ELPElastin-like polypeptides

GDFGrowth differentiation factor

GFPGreen fluorescent protein

HApHydroxyapatite

HA-PEIPEI conjugated with hyaluronic acids

hBMSCHuman bone-marrow-derived mesenchymal stem cell

HDFHuman dermal fibroblasts

hEGFHuman epidermal growth factor

HFPHexafluoro-2-propanol

KGFKeratinocyte growth factor

LBLLayer-by-layer

MMPMatrix metalloproteinase

NPCNeural progenitor cell

NSENanofibers-based sandwich electroporation

PBAEPolycationic polyβ-amino ester

PCLPolycaprolactone

PCLEEPPolycaprolactone-co-ethylethylene phosphate

PDPolydopamine

PDGFPlatelet-derived growth factor

PDLLAPolyD,L-lactide

PEGPolyethylene glycol

PEIPolyethylenimine

PELAPolyD,L-lactide-polyethylene glycol

PETPolyethylene terephthalate

PLAPolylactic acid

PLCLPolyL-lactide-co-ϵ-caprolactone

PLGAPolyD,L-lactide-co-glycolide

RESTRE-1 silencing transcription factor

siNEGNegative siRNA

RUNX2Runt-related transcription factor 2

shRNAShort hairpin RNA

siRNASmall interfering RNA

TGF-βTransforming growth factor-β

TSP-2Thrombospondin-2

VEGFVascular endothelial growth factor.

Electronic supplementary materialThe online version of this article doi:10.1186-1754-1611-8-30 contains supplementary material, which is available to authorized users.

Slgirim Lee, Gyuhyung Jin contributed equally to this work.

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Autor: Slgirim Lee - Gyuhyung Jin - Jae-Hyung Jang

Fuente: https://link.springer.com/



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