An open label pilot study to evaluate the efficacy of Spanish black radish on the induction of phase I and phase II enzymes in healthy male subjectsReportar como inadecuado




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BMC Complementary and Alternative Medicine

, 14:475

Clinical research

Abstract

BackgroundHumans are exposed to toxins which accumulate in the body, and are detoxified primarily in the liver. Studies have shown that cruciferous vegetables such as radishes may be beneficial to health by aiding detoxification of toxins in the liver.

MethodsThis single-centre, open-label, pilot study investigated the effect of a dietary supplement containing Spanish Black Radish on hepatic function in healthy males by monitoring the profiles of plasma and urine acetaminophen metabolites and serum hormone concentrations at baseline and after 4 weeks of supplementation. A paired t-test was used to compare pre- and post-treatment of plasma and urine acetaminophen metabolite profiles, serum hormone concentrations and safety end points.

ResultsArea under the curve AUC from 0 to 8 hours for the acetaminophen glucuronide metabolite and unchanged acetaminophen in plasma decreased from baseline to week 4 by 9% P = 0.004 and 40% P = 0.010, respectively. The AUC from 0 to 8 hours for acetaminophen sulfate and mercapturate metabolites in the urine increased by 11% P = 0.010 and 37% P = 0.024, respectively, from baseline to week 4. The AUC from 0 to 8 hours of serum estradiol-17β decreased by 10% from baseline to week 4 P = 0.005. All measures of clinical safety remained within acceptable laboratory ranges, however a significant reduction in plasma γ-glutamyl transferase levels was noted after 4 weeks of Spanish Black Radish treatment P = 0.002.

ConclusionsThese changes in metabolite and hormone levels indicate that Spanish Black Radish supplements have a positive influence on the detoxification of acetaminophen suggesting up-regulation of phase I and phase II liver enzymes. This study was sponsored by Standard Process Inc.

Trial registrationClinicalTrials.gov registration numberNCT02137590 Date of registration: May 12, 2014

KeywordsSpanish black radish Detoxification Hepatic function AbbreviationsALTAlanine aminotransferase

ASTAspartate aminotransferase

AUCConcentration time curve

BMIBody mass index

AUCArea under the concentration time curve

CmaxMaximum concentration

CYPCytochrome P450

GGTGlutamyl transferase

GSHGlutathione

HPLCHigh performance liquid chromatography

NAPQIN-acetyl-p-benzoquinone

SBRSpanish black radish

TmaxTime of maximum concentration.

Electronic supplementary materialThe online version of this article doi:10.1186-1472-6882-14-475 contains supplementary material, which is available to authorized users.

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Autor: Malkanthi Evans - Elaine Paterson - David M Barnes

Fuente: https://link.springer.com/







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