Co-infection with Schistosoma mansoni and Human Immunodeficiency Virus-1 HIV-1 among residents of fishing villages of north-western TanzaniaReportar como inadecuado

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Parasites and Vectors

, 7:587

First Online: 16 December 2014Received: 20 October 2014Accepted: 02 December 2014


BackgroundCo-infection with S. mansoni and Human Immunodeficiency Virus-1 HIV-1 has been described in sub-Saharan Africa. However, few community-based studies have been conducted to assess the association between the two diseases. The present study examined whether the infection with HIV-1 is associated with an altered susceptibility to S. mansoni infection by comparing the prevalence and intensity of S. mansoni infection among those infected and not infected with HIV-1. Any influence of HIV-1 associated immunodeficiency on the intensity of S. mansoni infection was also investigated.

MethodsA cross-sectional study was conducted among 1,785 randomly selected adults aged 21–55 years in fishing villages of north-western Tanzania. Single stool samples were obtained and examined for S. mansoni eggs using the Kato Katz technique. Finger prick and venous blood samples were collected for HIV-1 screening and CD4 cell quantification. Demographic information was collected by questionnaire.

ResultsOf the 1,785 individuals from whom complete data were obtained, 854 47.85%, 95% CI; 40.46 – 56.57 were infected with S. mansoni and had a mean intensity of 183.2195% CI; 165.61-202.70 eggs per gram of faeces epg. A total of 125 individuals 6.29%, 95% CI 3.59-11.04 were infected with HIV-1 and only 40% n=50 of them were co-infected with S. mansoni. No differences in prevalence of S. mansoni infection or intensities of infection, as estimated by egg count epg, were observed between HIV-1 sero-positive individuals and HIV-1 negative individuals. In generalized regression models adjusted for sex, age, occupation, residence and level of education, being infected with HIV-1 did not increase the risk APR=1.01, 95%; 0.83-1.21, P=0.93 or intensity AOR = 0.84, 95% CI; 0.56-1.25, P = 0.33 of S. mansoni infection. Among individuals co-infected with HIV-1 and S. mansoni infection, the intensity of infection epg was not associated P = 0.21 or correlated P = 0.13 with CD4 cell counts.

ConclusionOur findings suggest that HIV-1 infection may not have a major effect on S. mansoni infection or on the excretion of eggs from the co-infected individuals. However, further studies are needed to understand the biological interaction between HIV-1 and S. mansoni in a large cohort of co-infected individuals.

KeywordsS. mansoni HIV-1 Co-infection Fishing villages Risk factors Tanzania Electronic supplementary materialThe online version of this article doi:10.1186-s13071-014-0587-2 contains supplementary material, which is available to authorized users.

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Autor: Humphrey D Mazigo - David W Dunne - Shona Wilson - Safari M Kinung’hi - Angela Pinot de Moira - Frances M Jones - Dom


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