Lavender oil suppresses indoleamine 2,3-dioxygenase activity in human PBMCReportar como inadecuado




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BMC Complementary and Alternative Medicine

, 14:503

Basic research

Abstract

BackgroundLavender remedies have been used in traditional medicine because of antimicrobial, anti-inflammatory and mood alleviating effects, but underlying molecular mechanisms are not yet fully elucidated. Recently, studies investigating the effects of lavender oil in the context of psychiatric disorders have indicated potent pharmacological properties. Metabolism of tryptophan by indoleamine 2,3-dioxygenase IDO was found to provide a biochemical link between immunology and neuroendocrinology and to be a frequent target of natural products.

MethodsIn this in vitro study, interferences of lavender oil and constituents -linalool, +-α-pinene and +-limonene with tryptophan catabolism by IDO and formation of neopterin via guanosine triphosphate GTP-cyclohydrolase-I and of interferon-γ have been investigated using unstimulated and phytohemagglutinin PHA-stimulated human peripheral blood mononuclear cells PBMC.

ResultsTreatment with lavender oil dose-dependently suppressed PHA-induced tryptophan breakdown and kynurenine formation. Similar effects were observed for the three constituents. In parallel, formation of neopterin and interferon-γ was diminished upon lavender oil treatment. In unstimulated PBMC, effect of lavender oil treatment was similar, but less pronounced.

ConclusionData from this in vitro study suggest that lavender oil treatment might contribute to the modulation of the immune and neuroendocrine system by interfering with activation-induced tryptophan breakdown and IDO activity.

KeywordsLavender oil Tryptophan Indoleamine 2,3-dioxygenase Neopterin Kynurenine Electronic supplementary materialThe online version of this article doi:10.1186-1472-6882-14-503 contains supplementary material, which is available to authorized users.

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Fuente: https://link.springer.com/



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