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BMC Infectious Diseases

, 14:678

Tuberculosis and other mycobacterial diseases

Abstract

BackgroundPrison conditions can favor the spread of tuberculosis TB. This study aimed to evaluate in a Brazilian prison: the performance and accuracy of smear, culture and Detect-TB; performance of smear plus culture and smear plus Detect-TB, according to different TB prevalence rates; and the cost-effectiveness of these procedures for pulmonary tuberculosis PTB diagnosis.

MethodsThis paper describes a cost-effectiveness study. A decision analytic model was developed to estimate the costs and cost-effectiveness of five routine diagnostic procedures for diagnosis of PTB using sputum specimens: a Smear alone, b Culture alone, c Detect-TB alone, d Smear plus culture and e Smear plus Detect-TB. The cost-effectiveness ratio of costs were evaluated per correctly diagnosed TB case and all procedures costs were attributed based on the procedure costs adopted by the Brazilian Public Health System.

ResultsA total of 294 spontaneous sputum specimens from patients suspected of having TB were analyzed. The sensibility and specificity were calculated to be 47% and 100% for smear; 93% and 100%, for culture; 74% and 95%, for Detect-TB; 96% and 100%, for smear plus culture; and 86% and 95%, for smear plus Detect-TB. The negative and positive predictive values for smear plus Detect-TB, according to different TB prevalence rates, ranged from 83 to 99% and 48 to 96%, respectively. In a cost-effectiveness analysis, smear was both less costly and less effective than the other strategies. Culture and smear plus culture were more effective but more costly than the other strategies. Smear plus Detect-TB was the most cost-effective method.

ConclusionsThe Detect-TB evinced to be sensitive and effective for the PTB diagnosis when applied with smear microscopy. Diagnostic methods should be improved to increase TB case detection. To support rational decisions about the implementation of such techniques, cost-effectiveness studies are essential, including in prisons, which are known for health care assessment problems.

KeywordsTuberculosis Cost-effectiveness Prison Detect-TB Molecular diagnosis IS6110 Electronic supplementary materialThe online version of this article doi:10.1186-s12879-014-0678-x contains supplementary material, which is available to authorized users.

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Autor: Karen Barros Schmid - Luciene Scherer - Regina Bones Barcellos - Daniele Kuhleis - Isaías Valente Prestes - Ricardo Ewba

Fuente: https://link.springer.com/







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