Genetically engineering encapsulin protein cage nanoparticle as a SCC-7 cell targeting optical nanoprobeReportar como inadecuado




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Biomaterials Research

, 18:21

First Online: 23 December 2014Received: 10 October 2014Accepted: 10 November 2014

Abstract

BackgroundProtein cage nanoparticles are promising nanoplatform candidates for efficient delivery systems of diagnostics and-or therapeutics because of their uniform size and structure as well as high biocompatibility and biodegradability. Encapsulin protein cage nanoparticle is used to develop a cell-specific targeting optical nanoprobe.

ResultsFcBPs are genetically inserted and successfully displayed on the surface of encapsulin to form FcBP-encapsulin. Selectively binding of FcBP-encapsulin to SCC-7 is visualized with fluorescent microscopy.

ConclusionsEncapsulin protein cage nanoparticle is robust enough to maintain their structure at high temperature and easily acquires multifunctions on demand through the combination of genetic and chemical modifications.

KeywordsEncapsulin Protein cage nanoparticle Cell targeting Nanoprobe Delivery Electronic supplementary materialThe online version of this article doi:10.1186-2055-7124-18-21 contains supplementary material, which is available to authorized users.

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Autor: Hyojin Moon - Jisu Lee - Hansol Kim - Somin Heo - Junseon Min - Sebyung Kang

Fuente: https://link.springer.com/







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