Adiposity markers and risk of coronary heart disease in patients with type 2 diabetes mellitusReportar como inadecuado




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Nutrition Journal

, 13:124

First Online: 23 December 2014Received: 04 June 2014Accepted: 05 December 2014

Abstract

BackgroundThis cross-sectional study aimed to evaluating the association between body adiposity markers and high-risk of coronary heart disease CHD in patients with type 2 diabetes.

MethodsRecent adiposity markers waist-to-height ratio, conicity index C-index and body adiposity index and traditional markers BMI, waist circumference and waist-to-hip ratio WHR were measured. The 10-year risk of fatal CHD was estimated according to UKPDS risk engine scores. Patients were divided into high CHD risk ≥20%; n = 99 or low-moderate CHD risk <20%; n = 321 risk groups. Multiple logistic regression models were performed to analyze associations between CHD risk outcome and adiposity markers.

ResultsA total of 420 patients with type 2 diabetes 61.9 ± 9.5 years; 53.5% females; HbA1c 7.6 ± 1.6% were evaluated. The high risk group had greater proportions of elevated C-index and BMI values than patients with low-moderate risk. No between-group differences in other adiposity markers were observed. In multiple logistic regression models, only C-index values ≥1.35 were associated with CHD risk >20% OR = 1.69; 95% CI 1.03-2.78; P = 0.039 after adjusting for confounders sedentary lifestyle, diabetic nephropathy, serum creatinine, and diabetes duration. The association between WHR and CHD risk did not hold in this sample.

ConclusionsThe C-index was the body adiposity marker best associated with high risk of fatal CHD in these patients with type 2 diabetes.

KeywordsAnthropometry Body fat distribution Obesity Abdominal Coronary disease Diabetes mellitus Type 2 AbbreviationsCHDCoronary heart disease

BMIBody mass index

WCWaist circumference

WHRWaist-hip ratio

WHtRWaist-height ratio

C-indexConicity index

BAIBody adiposity index

UKPDSUnited Kingdom Prospective Diabetes Study

HbA1cGlycosylated hemoglobin

HDLHigh-density lipoprotein

LDLLow-density lipoprotein

UAEUrinary albumin excretion.

Electronic supplementary materialThe online version of this article doi:10.1186-1475-2891-13-124 contains supplementary material, which is available to authorized users.

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Autor: Simone F Tonding - Flávia M Silva - Juliana P Antonio - Mirela J Azevedo - Luis Henrique S Canani - Jussara C Almeid

Fuente: https://link.springer.com/







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