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Abstract: The chemotactic pathway allows bacteria to respond and adapt to environmentalchanges, by tuning the tumbling and running motions that are due to clockwiseand counterclockwise rotations of their flagella. The pathway is tightlyregulated by feedback mechanisms governed by the phosphorylation andmethylation of several proteins. In this paper, we present a detailedmechanistic model for chemotaxis, that considers all of its transmembrane andcytoplasmic components, and their mutual interactions. Stochastic simulationsof the dynamics of a pivotal protein, CheYp, are performed by means of tauleaping algorithm. This approach is then used to investigate the interplaybetween the stochastic fluctuations of CheYp amount and the number of cellularflagella. Our results suggest that the combination of these factors mightrepresent a relevant component for chemotaxis. Moreover, we study the pathwayunder various conditions, such as different methylation levels and ligandamounts, in order to test its adaptation response. Some issues for future workare finally discussed.



Autor: Daniela Besozzi, Paolo Cazzaniga, Matteo Dugo, Dario Pescini, Giancarlo Mauri

Fuente: https://arxiv.org/







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