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BMC Pregnancy and Childbirth

, 13:173

Maternal health and pregnancy

Abstract

BackgroundHuman papillomavirus HPV is known to be more prevalent in spontaneous abortions than in elective terminations of pregnancy. More recently, placental infection with HPV was shown to be associated with spontaneous preterm delivery. However, no study has evaluated the prevalence of HPV infection in pregnant Korean females and its association with adverse pregnancy outcomes.

MethodsWe conducted a cross-sectional study of 311 females who gave birth at Korea University Medical Center. Our sample included 45 preterm deliveries, 50 cases of premature rupture of the membranes PROM, 21 preeclampsia cases, and 8 gestational diabetes mellitus GDM patients. We used the Hybrid Capture II system to detect high-risk HR-HPV infection at six weeks postpartum.

ResultsThe prevalence of HR-HPV infection was 14.1%. Women with HR-HPV infection had a higher incidence of PROM than those without HR-HPV. HR-HPV infection was associated with an increased risk of PROM OR, 2.380; 95% CI, 1.103-5.134. The prevalence of preterm delivery, preeclampsia, or GDM was not different between the two groups.

ConclusionsWe observed a high prevalence of HR-HPV infection in pregnant women. Moreover, HR-HPV infection was associated with a risk of PROM at term. Further studies are needed to evaluate mechanisms by which HR-HPV infection induces PROM.

KeywordsHuman papillomavirus Pregnancy Complication Electronic supplementary materialThe online version of this article doi:10.1186-1471-2393-13-173 contains supplementary material, which is available to authorized users.

GeumJoon Cho, Kyung-Jin Min contributed equally to this work.

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Autor: GeumJoon Cho - Kyung-Jin Min - Hye-Ri Hong - SuhngWook Kim - Jin-Hwa Hong - Jae-Kwan Lee - Min-Jeong Oh - HaiJoong Kim

Fuente: https://link.springer.com/



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