Pronuclear morphology evaluation for fresh in vitro fertilization IVF and intracytoplasmic sperm injection ICSI cycles: a systematic reviewReportar como inadecuado




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Journal of Ovarian Research

, 6:64

First Online: 12 September 2013Received: 05 June 2013Accepted: 16 August 2013

Abstract

The current systematic review was aimed to assess the effectiveness of the zygote morphology evaluation in fresh in vitro fertilization IVF and intracytoplasmic sperm injection ICSI cycles. All available studies reporting on zygote morphology and clinical and-or biological outcomes were analyzed. Forty studies were included in the final analysis. Fourteen different zygote scoring systems were employed. Zygote morphology correlated significantly with embryo quality and cleavage, blastocyst stage, embryonic chromosome status, in a high proportion of the studies which assessed the specific outcome 15-25 60%, 15-20 75%, 7-8 87.5%, 6-6 100%, respectively. On the other hand, only a reduced proportion of papers showed a statistically significant relationship between implantation, pregnancy and delivery-live-birth rates and zygote morphology score 12-23 52.2%, 12-25 48%, 1-4 25%, respectively. In conclusion, our findings demonstrate the lack of conclusive data on the clinical efficacy of the zygote morphology evaluation in fresh IVF-ICSI cycles, even if biological results showing a good relationship with embryo viability suggest a role in cycles in which the transfer-freezing is performed at day 1.

KeywordsARTs Embryo ICSI IVF Morphology Zygote AbbreviationsARTsAssisted reproductive technologies

CIConfidence interval

FISHFluorescence in situ hybridization

ICSIIntracytoplasmic sperm injection

IVFIn-vitro fertilization

NPBsNucleolar precursor bodies

OROdds ratio

PBsPolar bodies

PGDPreimplantation genetic diagnosis

PNPronuclear.

Electronic supplementary materialThe online version of this article doi:10.1186-1757-2215-6-64 contains supplementary material, which is available to authorized users.

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Autor: Alessia Nicoli - Stefano Palomba - Francesco Capodanno - Maria Fini - Angela Falbo - Giovanni Battista La Sala

Fuente: https://link.springer.com/



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