Effects of oral adenosine-5′-triphosphate supplementation on athletic performance, skeletal muscle hypertrophy and recovery in resistance-trained menReportar como inadecuado

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Nutrition and Metabolism

, 10:57

First Online: 22 September 2013Received: 19 June 2013Accepted: 13 September 2013


BackgroundCurrently, there is a lack of studies examining the effects of adenosine-5′-triphosphate ATP supplementation utilizing a long-term, periodized resistance-training program RT in resistance-trained populations. Therefore, we investigated the effects of 12 weeks of 400 mg per day of oral ATP on muscular adaptations in trained individuals. We also sought to determine the effects of ATP on muscle protein breakdown, cortisol, and performance during an overreaching cycle.

MethodsThe study was a 3-phase randomized, double-blind, and placebo- and diet-controlled intervention. Phase 1 was a periodized resistance-training program. Phase 2 consisted of a two week overreaching cycle in which volume and frequency were increased followed by a 2-week taper Phase 3. Muscle mass, strength, and power were examined at weeks 0, 4, 8, and 12 to assess the chronic effects of ATP; assessment performance variables also occurred at the end of weeks 9 and 10, corresponding to the mid and endpoints of the overreaching cycle.

ResultsThere were time p < 0.001, and group x time effects for increased total body strength +55.3 ± 6.0 kg ATP vs. + 22.4 ± 7.1 kg placebo, p < 0.001; increased vertical jump power + 796 ± 75 ATP vs. 614 ± 52 watts placebo, p < 0.001; and greater ultrasound determined muscle thickness +4.9 ± 1.0 ATP vs. 2.5 ± 0.6 mm placebo, p < 0.02 with ATP supplementation. During the overreaching cycle, there were group x time effects for strength and power, which decreased to a greater extent in the placebo group. Protein breakdown was also lower in the ATP group.

ConclusionsOur results suggest oral ATP supplementation may enhance muscular adaptations following 12-weeks of resistance training, and prevent decrements in performance following overreaching. No statistically or clinically significant changes in blood chemistry or hematology were observed.

Trial registrationClinicalTrials.gov NCT01508338

KeywordsAdenosine triphosphate Exercise performance Power Strength Muscle hypertrophy Sports nutrition AbbreviationsATPAdenosine-5′-triphosphate

CkCreatine kinase

cGMPCurrent Good Manufacturing Practices

DXADual-energy x-ray absorptiometry

LBMLean body mass

PPPeak power


RTResistance training.

Electronic supplementary materialThe online version of this article doi:10.1186-1743-7075-10-57 contains supplementary material, which is available to authorized users.

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Autor: Jacob M Wilson - Jordan M Joy - Ryan P Lowery - Michael D Roberts - Christopher M Lockwood - Anssi H Manninen - John 

Fuente: https://link.springer.com/

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