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Journal of Natural Medicines

, Volume 67, Issue 4, pp 677–689

First Online: 17 April 2013Received: 18 June 2012Accepted: 12 March 2013


Dengue fever causes mortality and morbidity around the world, specifically in the Tropics and subtropic regions, which has been of major concern to governments and the World Health Organization WHO. As a consequence, the search for new anti-dengue agents from medicinal plants has assumed more urgency than in the past. Medicinal plants have been used widely to treat a variety of vector ailments such as malaria. The demand for plant-based medicines is growing as they are generally considered to be safer, non-toxic and less harmful than synthetic drugs. This article reviews potential anti-dengue activities from plants distributed around the world. Sixty-nine studies from 1997 to 2012 describe 31 different species from 24 families that are known for their anti-dengue activities. About ten phytochemicals have been isolated from 11 species, among which are compounds with the potential for development of dengue treatment. Crude extracts and essential oils obtained from 31 species showed a broad activity against Flavivirus. Current studies show that natural products represent a rich potential source of new anti-dengue compounds. Further ethnobotanical surveys and laboratory investigations are needed established the potential of identified species in contributing to dengue control.

KeywordsDengue fever Anti-dengue Medicinal plants Phytochemical AbbreviationsCC50Cytotoxicity concentration

DENVDengue virus

DFDengue fever

DHFDengue hemorrhagic fever

DSSDengue shock syndrome

HPLCHigh performance liquid chromatography

IC50Inhibitory concentration

MNTDMaximum non-toxic dose

MTT3-4,5-Dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide

TCID50Median tissue culture infective dose

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Author: Siti Latifah Abd Kadir - Harisun Yaakob - Razauden Mohamed Zulkifli

Source: https://link.springer.com/


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