The association of very-low-density lipoprotein with ankle-brachial index in peritoneal dialysis patients with controlled serum low-density lipoprotein cholesterol levelReport as inadecuate

The association of very-low-density lipoprotein with ankle-brachial index in peritoneal dialysis patients with controlled serum low-density lipoprotein cholesterol level - Download this document for free, or read online. Document in PDF available to download.

BMC Nephrology

, 14:212

Clinical Research


BackgroundPeripheral artery disease PAD represents atherosclerotic disease and is a risk factor for death in peritoneal dialysis PD patients, who tend to show an atherogenic lipid profile. In this study, we investigated the relationship between lipid profile and ankle-brachial index ABI as an index of atherosclerosis in PD patients with controlled serum low-density lipoprotein LDL cholesterol level.

MethodsThirty-five PD patients, whose serum LDL cholesterol level was controlled at less than 120mg-dl, were enrolled in this cross-sectional study in Japan. The proportions of cholesterol level to total cholesterol level cholesterol proportion in 20 lipoprotein fractions and the mean size of lipoprotein particles were measured using an improved method, namely, high-performance gel permeation chromatography. Multivariate linear regression analysis was adjusted for diabetes mellitus and cardiovascular and-or cerebrovascular diseases.

ResultsThe mean standard deviation age was 61.6 10.5 years; PD vintage, 38.5 28.1 months; ABI, 1.07 0.22. A low ABI 0.9 or lower was observed in 7 patients low-ABI group. The low-ABI group showed significantly higher cholesterol proportions in the chylomicron fraction and large very-low-density lipoproteins VLDLs Fractions 3–5 than the high-ABI group ABI>0.9. Adjusted multivariate linear regression analysis showed that ABI was negatively associated with serum VLDL cholesterol level parameter estimate=-0.00566, p=0.0074; the cholesterol proportions in large VLDLs Fraction 4, parameter estimate=-3.82, p=0.038; Fraction 5, parameter estimate=-3.62, p=0.0039 and medium VLDL Fraction 6, parameter estimate=-3.25, p=0.014; and the size of VLDL particles parameter estimate=-0.0352, p=0.032.

ConclusionsThis study showed that the characteristics of VLDL particles were associated with ABI among PD patients. Lowering serum VLDL level may be an effective therapy against atherosclerosis in PD patients after the control of serum LDL cholesterol level.

KeywordsPeritoneal dialysis Ankle-brachial index Very low density lipoprotein Atherosclerosis Peripheral artery disease Chromatography AbbreviationsPADPeripheral artery disease

PDPeritoneal dialysis

ABIAnkle-brachial index

LDLLow-density lipoprotein

Cholesterol ProportionProportions of cholesterol levels to total cholesterol level

VLDLVery-low-density lipoprotein

ESRDEnd-stage renal disease

TASC2Trans-Atlantic Inter-Society Consensus 2 for the management of PAD

DMDiabetes mellitus


LDL-CLDL cholesterol

HDL-CHigh-density lipoprotein cholesterol

K-DOQIKidney disease outcomes quality initiative

HPGPCHigh-performance gel permeation chromatography

HDLHigh-density lipoprotein cholesterol

CVDCardiovascular and-or cerebrovascular diseases

PTHParathyroid hormone


F1Fraction 1

VLDL-CVLDL cholesterol

CM-CCM cholesterol

logCMnatural logarithm value of CM-C level

logTGnatural logarithm value of TG level

Low-ABI groupa group of patients with low ABI 0.9 or low

BMIBody mass index

D-P Crdialysate-plasma creatinine ratio

univariateunivariate linear regression analysis

multivariatelinear regression analysis

rPearson’s correlation coefficient.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2369-14-212 contains supplementary material, which is available to authorized users.

Eiichiro Kanda, Masumi Ai, Mitsuyo Okazaki, Yoshitaka Maeda, Sei Sasaki and Masayuki Yoshida contributed equally to this work.

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Author: Eiichiro Kanda - Masumi Ai - Mitsuyo Okazaki - Yoshitaka Maeda - Sei Sasaki - Masayuki Yoshida


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