Antibiotic resistance among Escherichia coli isolates from stool samples of children aged 3 to 14 years from Ujjain, IndiaReportar como inadecuado




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BMC Infectious Diseases

, 13:477

Bacterial and fungal diseases

Abstract

BackgroundAntibiotic resistance is a major global public health concern, particularly in settings where few treatment options are available. Limited research has been done on antibiotic resistance in Escherichia coli of Indian children at community level. Therefore we studied antibiotic resistance patterns in E. coli isolates from stool samples of children aged 3-14 years from Ujjain, Central India, to investigate associations of resistance with demographic variables.

MethodsChildren, 3-14 years of age, were included from 30 randomly selected villages of Palwa demographic surveillance site, Ujjain, India. Parents were interviewed using a questionnaire, and stool samples were collected from participating children. E. coli were isolated from stool samples n = 529, and susceptibility testing to 18 different antibiotics was done using standard methods.

ResultsThe proportions of isolates resistant to various antibiotics were, nalidixic acid, 45%, tetracycline 37%, ampicillin 37%, sulfamethoxazole-trimethoprim 29% and amoxicillin-clavulanic acid 29%. No isolates were resistant to imipenem. Overall, 72% of isolates were resistant to at least one antibiotic and 33% were multi-drug resistant. High rates of cross-resistance were seen for 15 83% of the antibiotics studied. E. coli isolates from children with literate mothers were more resistant to penicillins and fluoroquinolones. ESBL-producers comprised 9% of the isolates.

ConclusionAntibiotic resistance and cross-resistance were common in E. coli from stools of children. Resistance rates were associated with maternal literacy.

KeywordsE. coli Faecal Children Commensal Antibiotic resistance Asia Electronic supplementary materialThe online version of this article doi:10.1186-1471-2334-13-477 contains supplementary material, which is available to authorized users.

Pragya Shakya, Peter Barrett, Vishal Diwan contributed equally to this work.

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Autor: Pragya Shakya - Peter Barrett - Vishal Diwan - Yogyata Marothi - Harshada Shah - Neeraj Chhari - Ashok J Tamhankar - Ashis

Fuente: https://link.springer.com/



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