Effects of aqueous leaf extract of Asystasia gangetica on the blood pressure and heart rate in male spontaneously hypertensive Wistar ratsReportar como inadecuado




Effects of aqueous leaf extract of Asystasia gangetica on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Complementary and Alternative Medicine

, 13:283

Basic research

Abstract

BackgroundAsystasia gangentica A. gangetica belongs to the family Acanthaceae. It is used to treat hypertension, rheumatism, asthma, diabetes mellitus, and as an anthelmintic in South Africa, India, Cameroun, Nigeria, and Kenya respectively. It has also been reported to inhibit the angiotensin I converting enzyme ACE in-vitro. Therefore, the aim of this study is to investigate the in-vivo effect of aqueous leaf extract ALE of A. gangetica on the blood pressure BP and heart rate HR in anaesthetized male spontaneously hypertensive rats SHR; and to elucidate possible mechanisms by which it acts.

MethodsThe ALE of A. gangetica 10–400 mg-kg, angiotensin I human acetate salt hydrate ANG I, 3.1–100 μg-kg and angiotensin II human ANG II, 3.1–50 μg-kg were administered intravenously. The BP and HR were measured via a pressure transducer connecting the femoral artery to a Powerlab and a computer for recording.

ResultsA. gangetica significantly p<0.05, and dose-dependently reduced the systolic, diastolic, and mean arterial BP. The significant p<0.05 reductions in HR were not dose-dependent. Both ANG I and ANG II increased the BP dose-dependently. Co-infusion of A. gangetica 200 mg-kg with either ANG I or ANG II significantly p<0.05 suppressed the hypertensive effect of both ANG I and ANG II respectively, and was associated with reductions in HR.

ConclusionsA. gangetica ALE reduced BP and HR in the SHR. The reduction in BP may be a result of actions of the ALE on the ACE, the ANG II receptors and the heart rate.

KeywordsAsystasia gangetica Blood pressure Heart rate Spontaneously hypertensive rats Renin angiotensin aldosterone system AbbreviationsA. gangeticaAsystasia gangentica

ACEAngiotensin I converting enzyme

ALEAqueous leaf extract

ANG IAngiotensin I

ANG IIAngiotensin II

AT1Angiotensin II type 1 receptor

BPBlood pressure

BpmBeats per minute

DBPDiastolic blood pressure

DMSODimethylsulfoxide

HRHeart rate

MAPMean arterial pressure

mmHgMillimetres of mercury

SBPSystolic blood pressure

SEMStandard error of mean

SHRSpontaneously hypertensive rats

UWCUniversity of the Western Cape.

Electronic supplementary materialThe online version of this article doi:10.1186-1472-6882-13-283 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Autor: Pierre Mugabo - Ismaila A Raji

Fuente: https://link.springer.com/



DESCARGAR PDF




Documentos relacionados