An in vitro study on the risk of non-allergic type-I like hypersensitivity to Momordica charantiaReportar como inadecuado




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BMC Complementary and Alternative Medicine

, 13:284

Basic research

Abstract

BackgroundMomordica charantia MC is a tropical plant that is extensively used in folk medicine. However, the knowledge about side effects of this plant is relatively little according to knowledge about its therapeutic effects. The aim of this study is to reveal the effects of non-allergic type-I like hypersensitivity to MC by an experiment which was designed in vitro.

MethodsIn the present study, the expression of CD63 and CD203c on peripheral blood basophils against different dilutions of MC extracts was measured using flow cytometry and compared with one another. In addition to this, intra-assay CV’s of testing extracts were calculated for precision on reproducibility of test results.

ResultsIt was observed that the fruit extract of MC at 1-100 and 1-1000 dilutions significantly increased active basophils compared to same extract at 1-10000 dilution.

ConclusionsIn conclusion, Momordica charantia may elicit a non-allergic type-I like hypersensitivity reaction in especially susceptible individuals.

KeywordsMomordica charantia Allergy Basophil activation AbbreviationsMCMomordica charantia

MFIMean fluorescent intensity

BATBasophil activation test.

Electronic supplementary materialThe online version of this article doi:10.1186-1472-6882-13-284 contains supplementary material, which is available to authorized users.

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Autor: Rahsan Ilikci Sagkan

Fuente: https://link.springer.com/



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