Serum retinol binding protein 4 is negatively related to beta cell function in Chinese women with non-alcoholic fatty liver disease: a cross-sectional studyReport as inadecuate

Serum retinol binding protein 4 is negatively related to beta cell function in Chinese women with non-alcoholic fatty liver disease: a cross-sectional study - Download this document for free, or read online. Document in PDF available to download.

Lipids in Health and Disease

, 12:157

First Online: 27 October 2013Received: 19 July 2013Accepted: 25 October 2013


BackgroundTo observe the relationship between serum retinol binding protein 4RBP4 and β cell function in Chinese subjects with non-alcoholic fatty liver disease NAFLD and without known diabetes.

Methods106 patients diagnosed as fatty liver by ultrasonography M-F: 61-45; aged 47.44 ± 14.16 years were enrolled in our current cross-sectional study. Subjects with known diabetes, chronic virus hepatitis and excessive alcohol consumption were excluded. Serum RBP4 was detected by ELISA and validated by quantitative Western blotting. β cell function were assessed by HOMA in all subjects and by hyperglycemic clamp in 17 normal glucose tolerance subjects M = 6, F = 11.

ResultsThe levels of serum RBP4 in men were higher than that in women 55.96 ± 11.14 vs 45.87 ± 10.31 μg-ml, p < 0.001. Pearson’s correlation analysis demonstrated that in women, serum RBP4 levels were significantly associated with fasting blood glucose FBG, HOMA-β, and increment of first phase insulin secretion 1PH, but not associated with age, BMI, waist circumference, WHR, systolic SBP and diastolic blood pressure DBP, TC, TG, HDL-c, LDL-c, 2 h blood glucose, HOMA-IR, ALT, AST, γ-GT, hepatic fat content HFC, and insulin sensitivity index ISI. However, in men, serum RBP4 levels were significantly associated with HDL-c, ALT, AST, but not associated with any other parameters as mentioned above. A stepwise multiple linear regression analysis demonstrated that in women, HOMA-IR and RBP4 were significantly associated with HOMA-β, while in men, HOMA-IR and BMI were significantly variables associated with HOMA-β.

ConclusionsSerum RBP4, secreted mainly by liver and adipose tissue, may involve in the pathogenesis of β cell dysfunction in Chinese women patients with NAFLD.

KeywordsSerum retinol binding protein 4 RBP4 Beta cell function Non-alcoholic fatty liver disease NAFLD AbbreviationsRBP4Retinol binding protein 4

NAFLDNon-alcoholic fatty liver disease

FBGFasting blood glucose

1PHFirstphase insulin secretion

2PHSecond-phase insulin secretion

WHRWaist-to-hip ratio

SBPSystolic blood pressure

DBPDiastolic blood pressure

HFCHepatic fat content

ISIInsulin sensitivity index

OGTTOral glucose tolerance test

NGRNormal glucose regulation

I-IFGIsolated-impaired fasting glucose

I-IGTIsolated-impairedglucose tolerance

BMIBody mass index

TCTotal cholesterol


HDL-cHigh-density lipoprotein cholesterol

LDL-cLow-density lipoprotein cholesterol

IRInsulin resistance

ALTAlanine aminotransferase

ASTAspartate aminotransferase

ALPAlkaline phosphatase


FINSFasting insulin

2hINS2 hour insulin

AIRgAcute insulin response

AUC-IArea under the curve for insulin.

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Author: Hongmei Yan - Xinxia Chang - Mingfeng Xia - Hua Bian - Linshan Zhang - Huandong Lin - Gang Chen - Mengsu Zeng - Xin Gao


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