Antidepressant-like activity of turmerone in behavioral despair tests in miceReportar como inadecuado




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BMC Complementary and Alternative Medicine

, 13:299

Basic research

Abstract

BackgroundThe present study was undertaken to evaluate the anti-depressive activity of turmerone after one-week administration by using a mouse forced swimming test FST and tail suspension test TST.

MethodsAnimals were divided into four groups n = 10 -group: control 0.9% saline, the three doses of turmerone 1.25, 2.5, 5.0 mg-kg for one-week treatment. To assess the effect of turmerone on locomotor activity, mice were evaluated in the open-field paradigm. Forced swimming test FST and Tail suspension test TST were used to take as a measure of antidepressant activity. The probable mechanisms of action of the anti-depressive effect of turmerone was also investigated by measuring the activity of monoamine oxidase-A and corticosterone levels in the blood and the levels of monoamines in the cortex, striatum, hippocampus and hypothalamus of the mice.

ResultsTurmerone 2.5, 5.0 mg-kg, p.o. significantly reduced the immobility time of mice in both the FST and TST, but it did not significantly affect the ambulatory and total movements of mice. However, hyperactivity might explain the results. In addition, turmerone decreased the corticosterone level in the blood while it increased the levels of 5-HT in cortex, striatum, hippocampus, and hypothalamus, the level of NE in striatum and hippocampus, the levels of MHPG and DOPAC in hypothalamus, the level of 5-HIAA in striatum, and the level of DA in striatum, hippocampus, and hypothalamus. Turmerone 2.5, 5.0 mg-kg decreased the activity of MAO-A in the frontal cortex and hippocampus of mouse brain.

ConclusionsAfter one-week administration, turmerone produced antidepressant-like effects. The mechanisms of action of anti-depressive effect of turmerone seemed to involve an increase of the monoamines level decreasing the MAO-A activity and the stress of mice.

KeywordsTumerone Forced swimming test Tail suspension test Antidepressant Monoamines Jung-Chun Liao, Chia-Yu Liu contributed equally to this work.

Electronic supplementary materialThe online version of this article doi:10.1186-1472-6882-13-299 contains supplementary material, which is available to authorized users.

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Autor: Jung-Chun Liao - Jen-Chieh Tsai - Chia-Yu Liu - Hui-Chi Huang - Lung-Yuan Wu - Wen-Huang Peng

Fuente: https://link.springer.com/







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