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Lipids in Health and Disease

, 12:162

First Online: 01 November 2013Received: 11 September 2013Accepted: 25 October 2013


BackgroundThis is a cross-sectional study with the objective to analyze lipid parameters of individuals living in Brazilian Amazon, where malaria is endemic.

MethodsThe city chosen was Anajás in the state of Pará, Brazil, in Amazon region. The study analyzed lipid parameters of 46 subjects, 31 male and 15 female, aged between 20–60 years without malaria, and residents for more than five years in this city considered an area hyperendemic for disease. It was established three groups according to the number of previous episodes of malaria: group I n = 22 one to five episodes, group II n = 20 six to ten episodes and group III n = 4 eleven to fifteen episodes. Total cholesterol, high density lipoprotein HDL cholesterol, and low density lipoprotein LDL cholesterol were measured and was confected the thick smear for malaria of all individuals.

ResultsThe hypocholesterolemia, the main characteristic of hyperendemic areas for malaria, was confirmed, but the mean of HDL cholesterol levels were 9.78% higher than the reference of World Health Organization.

ConclusionAlthough other factors might have contributed to lipid profile, the constant exposure to infection by Plasmodium, according to the physiology of the parasite, may have played an important role in defining the lipid parameters observed for this region. Further studies, such as the case–control is needed to confirm this hypothesis.

KeywordsMalaria Cholesterol Plasmodium AbbreviationsAPIAnnual parasite incidence

HDLHigh density lipoprotein

LDLLow density lipoprotein.

Electronic supplementary materialThe online version of this article doi:10.1186-1476-511X-12-162 contains supplementary material, which is available to authorized users.

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Autor: Frederico AR Neves - Ana MRS Ventura - Manoel GS Filho - Rosana MF Libonati


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