FGF-23 associated with the progression of coronary artery calcification in hemodialysis patientsReportar como inadecuado




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BMC Nephrology

, 14:241

Clinical Research

Abstract

BackgroundDisordered mineral metabolism is implicated in the pathogenesis of vascular calcification in hemodialysis HD patients. Fibroblast growth factor 23 FGF-23 is the main regulator of phosphate metabolism. In this prospective study, we aimed to investigate the association of serum FGF-23 with progression of coronary artery calcification in HD patients.

MethodsSeventy-four HD patients 36 male-38 female, mean age: 52 ± 14 years were included. Serum FGF-23 levels were measured by ELISA. Coronary artery calcification score CACS was measured twice with one year interval. Patients were grouped as progressive PG 36 patients-48% and non-progressive NPG.

ResultsAge, serum phosphorus, baseline and first year CACS were found to be significantly higher in the PG compared to NPG group. Serum FGF-23 levels were significantly higher in PG 155 80–468 vs 147 82–234, p = 0.04. Patients were divided into two groups according to baseline CACS low group, CACS ≤ 30; high group, CACS > 30. Serum FGF-23 levels were significantly correlated with the progression of CACS ΔCACS in the low baseline CACS group r = 0.51, p = 0.006, but this association was not found in high baseline CACS group r = 0.11, p = 0.44. In logistic regression analysis for predicting the PG patients; serum FGF-23, phosphorus levels and baseline CACS were retained as significant factors in the model.

ConclusionsSerum FGF-23 was found to be related to progression of CACS independent of serum phosphorus levels. FGF-23 may play a major role in the progression of vascular calcification especially at the early stages of calcification process in HD patients.

KeywordsFibroblast growth factor-23 Coronary artery calcification Vascular calcification Hemodialysis Electronic supplementary materialThe online version of this article doi:10.1186-1471-2369-14-241 contains supplementary material, which is available to authorized users.

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Autor: Abdullah Ozkok - Cigdem Kekik - Gonca Emel Karahan - Tamer Sakaci - Alper Ozel - Abdulkadir Unsal - Alaattin Yildiz

Fuente: https://link.springer.com/







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