Pomegranate vinegar attenuates adiposity in obese rats through coordinated control of AMPK signaling in the liver and adipose tissueReport as inadecuate

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Lipids in Health and Disease

, 12:163

First Online: 02 November 2013Received: 10 September 2013Accepted: 29 October 2013


BackgroundThe effect of pomegranate vinegar PV on adiposity was investigated in high-fat diet HF-induced obese rats.

MethodsThe rats were divided into 5 groups and treated with HF with PV or acetic acid 0, 6.5 or 13% w-w for 16 weeks. Statistical analyses were performed by the Statistical Analysis Systems package, version 9.2.

ResultsCompared to control, PV supplementation increased phosphorylation of AMP-activated protein kinase AMPK, leading to changes in mRNA expressions: increases for hormone sensitive lipase and mitochondrial uncoupling protein 2 and decreases for sterol regulatory element binding protein-1c SREBP-1c and peroxisome proliferator-activated receptorγ PPARγ in adipose tissue; increases for PPARα and carnitinepalmitoyltransferase-1a CPT-1a and decrease for SREBP-1c in the liver. Concomitantly, PV reduced increases of body weight p = 0.048, fat mass p = 0.033, hepatic triglycerides p = 0.005, and plasma triglycerides p = 0.001.

ConclusionsThese results suggest that PV attenuates adiposity through the coordinated control of AMPK, which leads to promotion of lipolysis in adipose tissue and stimulation of fatty acid oxidation in the liver.

KeywordsHigh-fat diet-induced obesity Pomegranate vinegar AMP-activated protein kinase Hormone sensitive lipase Fatty acid oxidation AbbreviationsACOAcyl-CoA oxidase

AMPKAMP-activated protein kinase


HFHigh-fat diet

HSLHormone sensitive lipase

PPARPeroxisome proliferator-activated receptor

PVPomegranate vinegar

SREBP-1cSterol regulatory element binding protein-1c


UCP-2Uncoupling protein-2

WATWhite adipose tissue.

Electronic supplementary materialThe online version of this article doi:10.1186-1476-511X-12-163 contains supplementary material, which is available to authorized users.

Elly Ok, Gyeong-Min Do contributed equally to this work.

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Author: Elly Ok - Gyeong-Min Do - Yeni Lim - Ji-Eun Park - Yeo-Jin Park - Oran Kwon

Source: https://link.springer.com/

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