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Lipids in Health and Disease

, 12:171

First Online: 09 November 2013Received: 25 September 2013Accepted: 07 November 2013


Along with rising numbers of patients with metabolic syndrome, the prevalence of nonalcoholic fatty liver disease NAFLD has increased in proportion with the obesity epidemic. While there are no established treatments for NAFLD, current research is targeting new molecular mechanisms that underlie NAFLD and associated metabolic disorders. This review discusses some of these emerging molecular mechanisms and their therapeutic implications for the treatment of NAFLD. The basic research that has identified potential molecular targets for pharmacotherapy will be outlined.

KeywordsNonalcoholic fatty liver disease Molecular mechanisms Electronic supplementary materialThe online version of this article doi:10.1186-1476-511X-12-171 contains supplementary material, which is available to authorized users.

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Autor: Yue Ye Huang - Aaron M Gusdon - Shen Qu


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