The effect of preoperative chemoradiotherapy on lymph nodes harvested in TME for rectal cancerReportar como inadecuado

The effect of preoperative chemoradiotherapy on lymph nodes harvested in TME for rectal cancer - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

World Journal of Surgical Oncology

, 11:292

First Online: 18 November 2013Received: 08 March 2012Accepted: 27 June 2013


BackgroundAdequate lymph nodes resection in rectal cancer is important for staging and local control. This retrospective analysis single center study evaluated the effect of neoadjuvant chemoradiation on the number of lymph nodes in rectal carcinoma, considering some clinicopathological parameters.

MethodsA total of 111 patients undergone total mesorectal excision for rectal adenocarcinoma from July 2005 to May 2012 in our center were included. No patient underwent any prior pelvic surgery or radiotherapy. Chemoradiotherapy was indicated in patients with rectal cancer stage II or III before chemoradiation.

ResultsOne-hundred and eleven patients were considered. The mean age was 67.6 yrs range 36 – 84, SD 10.8. Fifty 45.0% received neoadjuvant therapy before resection. The mean number of removed lymph nodes was 13.6 range 0–39, SD 7.3. In the patients who received neoadjuvant therapy the number of nodes detected was lower 11.5, SD 6.5 vs. 15.3, SD 7.5, p = 0.006. 37.4% of patients with preoperative chemoradiotherapy had 12 or more lymph nodes in the specimen compared to the 63.6% of those who had surgery at the first step p: 0.006.

Other factors associated in univariate analysis with lower lymph nodes yield included stage p 0.005 and grade p 0.0003 of the tumour. Age, sex, tumor site, type of operation, surgeons and pathologists did not weight upon the number of the removed lymph nodes.

ConclusionIn TME surgery for rectal cancer, preoperative CRT results into a reduction of lymph nodes yield in univariate analisys and linear regression.

KeywordsChemoradiation Lymph nodes Neoadjuvant Rectal cancer AbbreviationsANOVAAnalysis of variance

APRAbdominalperineal resection


CTComputed tomography

LARLow anterior resection

MRIMagnetic resonance imaging

pTNMPathological tumor-node-metastasis

TMETotal mesorectal excision.

Download fulltext PDF

Autor: Stefano Scabini - Fabrizio Montecucco - Alessio Nencioni - Gabriele Zoppoli - Marina Sartini - Edoardo Rimini - Andrea Mass


Documentos relacionados