CD20, CD3, placental malaria infections and low birth weight in an area of unstable malaria transmission in Central SudanReportar como inadecuado

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Diagnostic Pathology

, 8:189

First Online: 18 November 2013Received: 23 August 2013Accepted: 13 November 2013


BackgroundMalaria during pregnancy is the main cause of low birth weight LBW in the tropics. There are few studies concerning B and T lymphocyte infiltrates in placental malaria infections or their potential association with LBW babies.

MethodsA case–control study was conducted at the Medani Hospital, Central Sudan. Cases were women who had LBW deliveries infants weighed < 2,500 g and controls were parturient women with normal birth weight babies. Sociodemographic and medical characteristics were gathered from both groups of women using questionnaires. Cases and controls were investigated for malaria using microscopic blood film analysis, placental histology, and immunohistochemistry for detection of B CD20 and T lymphocytes CD3.

ResultsThe two groups 97 in each arm were well matched in their basic characteristics. There were no malaria-positive blood films in either the cases or the controls. Twenty-nine 30.0% vs. 24 24.7%, P = 0.519 of the cases vs. the controls had placental malaria infections on histological examination. Three 3.1%, two 2.1% and 24 24.7% vs. two 2.1%, two 2.1% and 20 20.6% of the placentae showed evidence of acute, chronic and past malarial infections on histopathological examination of the two groups case–control, respectively, while 68 70.1% vs. 73 75.3% of them showed no signs of infection; P = 0.420. Women with placental malaria infections had significantly fewer CD20 cell infiltrates 6 11.3% vs. 95 67.4%, P < 0.001 and higher numbers of CD3 cell infiltrates 50 94.3% vs. 42 29.8%, P < 0.001 than those without placental malaria infection. Logistic regression analysis showed that neither placental malaria infections nor CD3 or CD20 were associated with LBW.

ConclusionsSignificantly higher rates of CD3 T cells and lower rates of CD20 B cells were found in women with placental malaria infections compared with those without such infections. Neither placental malaria infection nor CD3 or CD20 are associated with LBW.


KeywordsMalaria Pregnancy Low birth weight CD20 CD3 Sudan Electronic supplementary materialThe online version of this article doi:10.1186-1746-1596-8-189 contains supplementary material, which is available to authorized users.

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Autor: Samah E Batran - Magdi M Salih - Elhassan M Elhassan - Ahmed A Mohmmed - Ishag Adam


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