Solubility of Omeprazole Sulfide in Different Solvents at the Range of 280.35–319.65 KReportar como inadecuado

Solubility of Omeprazole Sulfide in Different Solvents at the Range of 280.35–319.65 K - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Journal of Solution Chemistry

, Volume 42, Issue 12, pp 2342–2353

First Online: 12 November 2013Received: 25 April 2013Accepted: 07 September 2013


Solubility data were measured for omeprazole sulfide in ethanol, 95 mass-% ethanol, ethyl acetate, isopropanol, methanol, acetone, n-butanol and n-propanol in the temperature range from 280.35 to 319.65 K by employing the gravimetric method. The solubilities increase with temperature and they are in good agreement with the calculated solubility of the modified Apelblat equation and the λh equation. The experimental solubility and correlation equation in this work can be used as essential data and model in the purification process of omeprazole sulfide. The thermodynamic properties of the solution process, including the Gibbs energy, enthalpy, and entropy were calculated using the van’t Hoff equation.

KeywordsOmeprazole sulfide Solubility Gravimetric method Purification Solution thermodynamics  Download fulltext PDF

Autor: Yihua Li - Wenge Yang - Tuan Zhang - Chaoyuan Wang - Kai Wang - Yonghong Hu


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