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Drugs

, Volume 73, Issue 18, pp 2017–2029

First Online: 16 November 2013

Abstract

We review the current state of knowledge of remyelination in multiple sclerosis MS, concentrating on advances in the understanding of the pathology and the regenerative response, and we summarise progress on the development of new therapies to enhance remyelination aimed at reducing progressive accumulation of disability in MS. We discuss key target pathways identified in experimental models, as although most identified targets have not yet progressed to the stage of being tested in human clinical trials, they may provide treatment strategies for demyelinating diseases in the future. Finally, we discuss some of the problems associated with testing this class of drugs, where they might fit into the therapeutic arsenal and the gaps in our knowledge.

An erratum to this article can be found at http:-dx.doi.org-10.1007-s40265-013-0166-4.

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Autor: E. Jolanda Münzel - Anna Williams

Fuente: https://link.springer.com/



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