Dietary fatty acid intake is associated with paraoxonase 1 activity in a cohort-based analysis of 1,548 subjectsReportar como inadecuado

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Lipids in Health and Disease

, 12:183

First Online: 12 December 2013Received: 23 September 2013Accepted: 07 December 2013


BackgroundParaoxonase 1 PON1 is a cardioprotective, HDL-associated glycoprotein enzyme with broad substrate specificity. Our previous work found associations between dietary cholesterol and vitamin C with PON1 activity. The goal of this study was to determine the effect of specific dietary fatty acid DFA intake on PON1 activity.

Methods1,548 participants with paraoxonase activity measures completed the Harvard Standardized Food Frequency Questionnaire to determine their daily nutrient intake over the past year. Eight saturated, 3 monounsaturated, and 6 polyunsaturated DFAs were measured by the questionnaire. To reduce the number of observations tested, only specific fatty acids that were not highly correlated r < 0.8 with other DFAs or that were representative of other DFAs through high correlation within each respective group saturated, monounsaturated, or polyunsaturated were retained for analysis. Six specific DFA intakes – myristic acid 14 carbon atoms, no double bonds – 14:0, oleic acid 18:1, gadoleic acid 20:1, α-linolenic acid 18:3, arachidonic acid 20:4, and eicosapentaenoic acid 20:5 – were carried forward to stepwise linear regression, which evaluated the effect of each specific DFA on covariate-adjusted PON1 enzyme activity.

ResultsFour of the 6 tested DFA intakes – myristic acid p = 0.038, gadoleic acid p = 6.68 × 10, arachidonic acid p = 0.0007, and eicosapentaenoic acid p = 0.013 - were independently associated with covariate-adjusted PON1 enzyme activity. Myristic acid, a saturated fat, and gadoleic acid, a monounsaturated fat, were both positively associated with PON1 activity. Both of the tested polyunsaturated fats, arachidonic acid and eicosapentaenoic acid, were negatively associated with PON1 activity.

ConclusionsThis study presents the largest cohort-based analysis of the relationship between dietary lipids and PON1 enzyme activity. Further research is necessary to elucidate and understand the specific biological mechanisms, whether direct or regulatory, through which DFAs affect PON1 activity.

KeywordsParaoxonase 1 Dietary fatty acid intake Saturated fats Monounsaturated fats Polyunsaturated fats ω-3 fatty acids Cardiovascular disease Electronic supplementary materialThe online version of this article doi:10.1186-1476-511X-12-183 contains supplementary material, which is available to authorized users.

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Autor: Daniel Seung Kim - Sean K Maden - Amber A Burt - Jane E Ranchalis - Clement E Furlong - Gail P Jarvik


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