Roles and functions of HIV-1 Tat protein in the CNS: an overviewReportar como inadecuado




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Virology Journal

, 10:358

Retroviruses

Abstract

Nearly 50% of HIV-infected individuals suffer from some form of HIV-associated neurocognitive disorders HAND. HIV-1 Tat a key HIV t ransa ctivator of t ranscription protein is one of the first HIV proteins to be expressed after infection occurs and is absolutely required for the initiation of the HIV genome transcription. In addition to its canonical functions, various studies have shown the deleterious role of HIV-1 Tat in the development and progression of HAND. Within the CNS, only specific cell types can support productive viral replication astrocytes and microglia, however Tat protein can be released form infected cells to affects HIV non-permissive cells such as neurons. Therefore, in this review, we will summarize the functions of HIV-1 Tat proteins in neural cells and its ability to promote HAND.

Electronic supplementary materialThe online version of this article doi:10.1186-1743-422X-10-358 contains supplementary material, which is available to authorized users.

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Autor: Asen Bagashev - Bassel E Sawaya

Fuente: https://link.springer.com/







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