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BMC Psychiatry

, 13:343

Psychotic disorders

Abstract

BackgroundThe aim of this comparative study was to investigate the type and frequency of diagnoses preceding adult bipolar disorder BD and schizophrenia SZ.

MethodsA follow-back study of all preceding diagnoses in all patients aged 21–34 years with a primary, first time diagnosis of BD N = 784 or SZ N = 1667 in 2008 to 2010. Data were taken from the Danish Psychiatric Central Research Register DPCRR including ICD-10 and ICD-8 diagnoses.

ResultsThe numbers of patients with any preceding diagnoses amounted to 69.3% in BD and 76.6% in SZ with affective disorders excluding BD being the most frequent preceding diagnosis 46.6 vs. 28.0%, followed by psychoses PSY other than SZ 14.2 vs. 41.5%, p < .001, and substance use disorders SUD 16.1 vs. 26.9%, p < .001. Reactions to severe stress were equally frequent in both samples 26.3 vs. 26.6% as were personality disorders 21.8 vs. 22.4% and ADHD 4.2 vs. 3.5%, whereas rates of conduct disorders 1.7 vs. 3.1% were rather low in both samples. Very few of the preceding diagnoses had their onset in childhood and adolescence. Overall patients with SZ had a minor but statistically significant earlier onset of any psychiatric disorder compared to BD mean age: 23.3 vs. 22.5, p < .001. Regression analyses indicated that BD was associated with an increased risk of having experienced preceding affective disorders and ADHD, while SZ was associated with an increased risk of preceding substance use disorders, psychosis, anxiety disorders, and personality disorders.

ConclusionsSpecific developmental trajectories of preceding disorders were delineated for BD and SZ with affective disorders being more specific for BD and both SUD and PSY more specific to SZ. There are different patterns of vulnerability in terms of preceding diagnosis in young adults with BD and SZ.

KeywordsFollow-back study Preceding diagnoses Bipolar disorders Schizophrenia Electronic supplementary materialThe online version of this article doi:10.1186-1471-244X-13-343 contains supplementary material, which is available to authorized users.

Søren Martin Andersen, Anne Randers, Christina Mohr Jensen contributed equally to this work.

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Autor: Søren Martin Andersen - Anne Randers - Christina Mohr Jensen - Charlotte Bisgaard - Hans-Christoph Steinhausen

Fuente: https://link.springer.com/







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