Pharmacokinetics and effect of intravenous meloxicam in weaned Holstein calves following scoop dehorning without local anesthesiaReportar como inadecuado




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BMC Veterinary Research

, 8:153

Pharmacology and toxicology

Abstract

BackgroundDehorning is a common practice involving calves on dairy operations in the United States. However, less than 20% of producers report using analgesics or anesthetics during dehorning. Administration of a systemic analgesic drug at the time of dehorning may be attractive to dairy producers since cornual nerve blocks require 10 – 15 min to take effect and only provide pain relief for a few hours. The primary objectives of this trial were to 1 describe the compartmental pharmacokinetics of meloxicam in calves after IV administration at 0.5 mg-kg and 2 to determine the effect of meloxicam n = 6 or placebo n = 6 treatment on serum cortisol response, plasma substance P SP concentrations, heart rate HR, activity and weight gain in calves after scoop dehorning and thermocautery without local anesthesia.

ResultsPlasma meloxicam concentrations were detectable for 50 h post-administration and fit a 2-compartment model with a rapid distribution phase mean T½α = 0.22 ± 0.087 h and a slower elimination phase mean T½β = 21.86 ± 3.03 h. Dehorning caused a significant increase in serum cortisol concentrations and HR P < 0.05. HR was significantly lower in the meloxicam-treated calves compared with placebo-treated calves at 8 h P = 0.039 and 10 h P = 0.044 after dehorning. Mean plasma SP concentrations were lower in meloxicam treated calves 71.36 ± 20.84 pg-mL compared with control calves 114.70 ± 20.84 pg-mL P = 0.038. Furthermore, the change in plasma SP from baseline was inversely proportional to corresponding plasma meloxicam concentrations P = 0.008. The effect of dehorning on lying behavior was less significant in meloxicam-treated calves p = 0.40 compared to the placebo-treated calves P < 0.01. Calves receiving meloxicam prior to dehorning gained on average 1.05 ± 0.13 kg bodyweight-day over 10 days post-dehorning compared with 0.40 ± 0.25 kg bodyweight-day in the placebo-treated calves p = 0.042.

ConclusionsTo our knowledge, this is the first published report examining the effects of meloxicam without local anesthesia on SP, activity and performance of calves post-dehorning. These findings suggest that administration of meloxicam alone immediately prior to dehorning does not mitigate signs of acute distress but may have long term physiological, behavior and performance effects.

KeywordsAnalgesia Meloxicam Dehorning Substance P Cortisol Heart rate Accelerometers Performance Electronic supplementary materialThe online version of this article doi:10.1186-1746-6148-8-153 contains supplementary material, which is available to authorized users.

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Autor: Johann F Coetzee - Ruby A Mosher - Butch KuKanich - Ronette Gehring - Brad Robert - J Brandon Reinbold - Brad J White

Fuente: https://link.springer.com/







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