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1 Saskatoon Research Centre 2 Anses Laboratoire de Fougères

Abstract : The 78th meeting of the Committee, at the request of the 21st Session of CCRVDF FAO-WHO,2014a, evaluated zilpaterol HCl and established an ADI of 0–0.04 µg-kg bw on the basis of aLOAEL for a slight increase of tremor in humans in a single dose study FAO-WHO, 2014b.The 78th meeting of the Committee also agreed that parent zilpaterol was an appropriate markerresidue in muscle. Only limited data were available for tissues other than muscle, and theCommittee was unable to determine a suitable marker residue in other edible tissues. Liver andkidney contained the highest concentration of zilpaterol at all sampling times, followed bymuscle. The ratios of the concentration of zilpaterol to the concentration of the total residuesfor liver and for kidney over the 96-hour withdrawal period after the last drug administrationcould not be determined with any confidence due to the very limited data available and lack ofsensitivity of the methods used. The data provided were not sufficient to determine the totalresidue half-life in the liver after 96 hours. There are no measurable residues in adipose fat.

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Keywords : analysis residues veterinary drug Zilpaterol hydrochloride

Mots-clés : analyse résidus médicament vétérinaire hydrochloride de zilpaterol





Autor: Joe Boison - Pascal Sanders - Alan Chicoine - Stefan Scheid -

Fuente: https://hal.archives-ouvertes.fr/



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