Prevalence and factors associated with nonalcoholic fatty liver disease in shanghai work-unitsReportar como inadecuado

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BMC Gastroenterology

, 12:123

Hepatobiliary and pancreatic disorders


BackgroundsNonalcoholic fatty liver disease NAFLD has become the most common chronic liver disease in Asians. However, data on prevalence and factors associated with NAFLD in Asians are lacking. The aim of this study is to investigate the prevalence of NAFLD in Shanghai employees to assess the relationship between NAFLD and age, gender, metabolic risk factors in this studied population.

MethodsWe selected 7152 employees of Shanghai work-units. Each of them underwent detailed medical history-taking, physical examination, laboratory assessments and abdominal ultrasonography. The diagnosis of NAFLD was done according to established criteria. Receiver operating characteristics ROC curves were applied to detect areas under the ROC curves for each index. Nominal logistic regression analysis was used to estimate the odds ratio for risk factors of NAFLD.

ResultsAbout 38.17% employees had NAFLD, more in men than in women. The prevalence of NAFLD increased with increasing age. In both genders, the prevalence of metabolic factors was higher in the NAFLD group. Body max index, waist circumference, weight-to-height ratio, blood pressure, blood glucose, total cholesterol, triglyceride, low density lipoprotein, high density lipoprotein and uric acid were found to have a diagnostic value for NAFLD. Body max index is a better index for diagnosing NAFLD. Uric acid is a new diagnosing index not inferior to lipid metabolic factors. Metabolic factors can increase the risk of NAFLD up to 1.5 ~ 3.8 times.

ConclusionsOlder age, male gender, metabolic factors such as obesity, abdominal obesity, dyslipidemia, hypertension or type 2 diabetes are risk factors for NAFLD. Prevalence of NAFLD in Shanghai employees is high. Prevention is extremely important. Those achieve the critical point should have early intervention.

KeywordsPrevalence Risk factors Nonalcoholic fatty liver AbbreviationsNAFLDNonalcoholic fatty liver disease

NASHNonalcoholic steatohepatitis

HCChepatocellular carcinoma

BMIBody mass index

WCwaist circumference

BPBlood pressure

SBPsystolic blood pressure

DBPdiastolic blood pressure


TCTotal cholesterol

HDL-CHigh Density Lipoprotein cholesterol

UAUric acid


FPGFasting plasma glucose

ALTAlanine transarninase

ASTAspartate aminotransferase

ANAantinuclear antibody

AMAantismooth muscle antibody

OGTTOral glucose tolerance test

USultrasonographic scan

T2DMtype 2 diabetes

ROCReceiver operating characteristics

AUCsareas under the ROC curves.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-230X-12-123 contains supplementary material, which is available to authorized users.

Xiaona Hu, Yiqin Huang contributed equally to this work.

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Autor: Xiaona Hu - Yiqin Huang - Zhijun Bao - Yiqian Wang - Dongmei Shi - Fang Liu - Zhanjuan Gao - Xiaofeng Yu


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