Evolution of blood pressure from adolescents to youth in salt sensitivies: a 18-year follow-up study in Hanzhong children cohortReportar como inadecuado




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Nutrition Journal

, 11:70

First Online: 14 September 2012Received: 11 March 2012Accepted: 07 September 2012

Abstract

BackgroundEssential hypertension mostly originates from children. Salt Sensitivity SS is regarded as the intermediate phenotype of essential hypertension. The present study investigated the effects of salt-sensitivity on evolution of blood pressure BP and development to hypertension from adolescents to youth.

MethodsA baseline survey was carried out in 4,623 adolescents aged 6-15 years old in Hanzhong rural areas in 1987, 310 of whommean 9.2 years were randomly recruited for determination of salt sensitivity using the tests of oral saline load and furosemide sodium-volume depletion. SS was diagnosed in 101 subjects while 209 were determined as non-salt-sensitive NSS. We made a 18-year followed-up of the cohort in 2005.

ResultsThe response rate for surviving baseline adolescents was 71.9%. At follow up, BP in youth with baseline SS was higher than that in NSS SBP:122.9 ± 13.1 VS 117.3 ± 12.4, P < 0.01; DBP: 78.2 ± 10.4 VS 74.7 ± 10.8, P < 0.05. Longitudinal analysis of 18-year BP evolution, subjects in SS had greater Systolic BP change than subjects in NSS19.6 ± 12.714.7 ± 12.2, P < 0.01. The incidence of hypertension in salt sensitive group was higher than that in NSS group 15.5% VS 6.3%, RR = 2.34, P < 0.05.

ConclusionOur findings indicate that adolescents with higher BP salt-sensitivity have a higher rate of incident hypertension in youth. Salt sensitivity could be at high risk predisposing to development of hypertension from adolescents to youth.

KeywordsBlood pressure Salt sensitivity Risk factor Adolescent AbbreviationsSSSalt sensitive

NSSNon-salt-sensitive

BPBlood pressure

BMIBody mass index

MABPMean arterial blood pressure

SBPSystolic blood pressure

DPBDiastolic blood pressure.

Electronic supplementary materialThe online version of this article doi:10.1186-1475-2891-11-70 contains supplementary material, which is available to authorized users.

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Autor: Jianjun Mu - Shuhui Zheng - Qiufang Lian - Fuqiang Liu - Zhiquan Liu

Fuente: https://link.springer.com/







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