The roots of Atractylodes japonica Koidzumi promote adipogenic differentiation via activation of the insulin signaling pathway in 3T3-L1 cellsReportar como inadecuado




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BMC Complementary and Alternative Medicine

, 12:154

Basic research

Abstract

BackgroundType 2 diabetes T2D is a complex metabolic disorder characterized by insulin resistance and hyperglycemia. Peroxisome proliferator-activated receptor gamma PPARγ is a key transcription factor and plays an important role in the regulation of genes involved in adipogenic differentiation, glucose metabolism and insulin signal transduction.

MethodsIn this study, the effects of the root extract of Atractylodes japonica Koidzumi Atractylodis Rhizoma Alba, ARA on the differentiation of 3T3-L1 preadipocytes and the possible mechanism of glucose transport were investigated. 3T3-L1 cells were cultured with insulin and ARA extract.

ResultsIn 3T3-L1 cells, ARA extract significantly enhanced adipogenic differentiation and upregulated the expression of PPARγ genes and protein in a dose-dependent manner. ARA also promoted glucose transport by increasing the glucose transporter 4 GLUT-4, phosphatidylinositol 3-kinase PI3K and insulin receptor substrates-1 IRS-1 levels.

ConclusionOur results suggest that ARA extract may be an attractive therapeutic agent for managing T2D via promoting the differentiation of adipocytes with the upregulation of PPARγ levels and the activation of the insulin signaling pathway.

KeywordsAtractylodes japonica Atractylodis Rhizoma Alba 3T3-L1 adipocyte PPARγ GLUT4 Insulin Type 2 diabetes Electronic supplementary materialThe online version of this article doi:10.1186-1472-6882-12-154 contains supplementary material, which is available to authorized users.

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Autor: Yunkyung Han - Hyo Won Jung - Yong-Ki Park

Fuente: https://link.springer.com/



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