The relationship between HBV serum markers and the clinicopathological characteristics of hepatitis B virus-associated glomerulonephritis HBV-GN in the northeastern chinese populationReportar como inadecuado




The relationship between HBV serum markers and the clinicopathological characteristics of hepatitis B virus-associated glomerulonephritis HBV-GN in the northeastern chinese population - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Virology Journal

, 9:200

First Online: 14 September 2012Received: 09 October 2011Accepted: 13 September 2012

Abstract

BackgroundTo investigate the effect of HBV markers on HBV-GN.

MethodsThe immunohistochemistry was used to detect HBsAg and HBcAg in frozen sections of renal biopsy, the changes in HBV serum markers, renal functional parameters and clinical manifestations or symptoms were observed to analyze renal damage.

ResultsUsing renal biopsy data from 329 cases, this study found that the most common pathological subtype in HBV-GN was mesangioproliferative glomerulonephritis MsPGN 24.9%, P <0.05, and 29.4% of patients who show serological HBsAg, HBeAg and anti-HBc positive developed membranoproliferative glomerulonephritis MPGN P <0.05. The immunohistochemistry was used to detect HBsAg and HBcAg in frozen sections.50% of HBsAg and HBcAg deposits was observed in the glomeruli of MPGN patients, while 36.6% of HBsAg and 43.9% of HBcAg deposited in the glomeruli of MsPGN patients. The deposits of HBsAg and HBcAg in glomeruli were directly correlated with IgA, IgG, IgM and C3 deposits. In addition, cases with a moderate to severe decrease as reflected by the glomerular filtration rate GFR were predominantly patients with MPGN 31.6%, P <0.05 or MsPGN 21.1%, P <0.05. Patients who were serological HBsAg, HBeAg and anti-HBc positive or HBsAg, anti-HBe and anti-HBc positive mainly exhibited urine and renal parameter changes.

ConclusionExamination of HBV markers in serum and renal biopsy will be useful for clinicians to predict the renal damage in early stage when it is reversible in HBV-GN.

KeywordsHBV serum markers Pathological subtype of hepatitis B virus-associated glomerulonephritis Renal functional parameters Clinical manifestations or symptoms AbbreviationsHBV-GNHepatitis B virus-associated glomerulonephritis

MsPGNMesangioproliferative glomerulonephritis

MPGNMembranoproliferative glomerulonephritis

MNMembranous nephropathy

MCGMinimal change glomerulopathy

GMLGlomerular minor lesion

IgANIgA Nephropathy

GFRGlomerular filtration rate

BUNBlood urea nitrogen

ScrSerum creatinine

HandEHematoxylin and eosin

PASMPeriodic acid-sliver methenamine.

Electronic supplementary materialThe online version of this article doi:10.1186-1743-422X-9-200 contains supplementary material, which is available to authorized users.

Lei Zhang, Hongxue Meng contributed equally to this work.

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Autor: Lei Zhang - Hongxue Meng - Xingying Han - Changsong Han - Chuanhui Sun - Fei Ye - Xiaoming Jin

Fuente: https://link.springer.com/



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