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Virology Journal

, 9:220

First Online: 28 September 2012Received: 03 February 2012Accepted: 14 September 2012


BackgroundDespite inducing a sustained increase in CD4+ T cell counts, intermittent recombinant IL-2 rIL-2 therapy did not confer a better clinical outcome in HIV-infected patients enrolled in large phase III clinical trials ESPRIT and SILCAAT. Several hypotheses were evoked to explain these discrepancies. Here, we investigated the impact of low and high doses of IL-2 in Rhesus macaques of Chinese origin infected with SIVmac251 in the absence of antiretroviral therapy ART.

ResultsWe demonstrated that rIL-2 induced a dose dependent expansion of CD4+ and CD8+ T cells without affecting viral load. rIL-2 increased CD4 and CD8 Treg cells as defined by the expression of CD25FoxP3CD127. We also showed that rIL-2 modulated spontaneous and Fas-mediated CD4 and CD8 T cell apoptosis. The higher dose exhibited a dramatic pro-apoptotic effect on both CD4 and CD8 T cell populations. Finally, all the animals treated with rIL-2 developed a wasting syndrome in the month following treatment simultaneously to a dramatic decrease of circulating effector T cells.

ConclusionThese data contribute to the understanding of the homeostatic and dosage effects of IL-2 in the context of SIV-HIV infection.

KeywordsSIV IL-2 immunotherapy T cells Apoptosis Fas Treg Electronic supplementary materialThe online version of this article doi:10.1186-1743-422X-9-220 contains supplementary material, which is available to authorized users.

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Autor: Julie Garibal - Mireille Laforge - Ricardo Silvestre - Shahul Mouhamad - Laure Campillo-Gimenez - Yves Lévy - Jérôme Est


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