Proliferation and bystander suppression induced by antigens of trypanosoma cruzi. evaluation with a modification of the t cell blot technique Reportar como inadecuado




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Niurka Navarro ; Yelitza Campos ; Luis Briceño ;Investigación Clínica 2006, 47 3

Autor: Walter Mosca

Fuente: http://www.redalyc.org/articulo.oa?id=372937664006


Introducción



Investigación Clínica ISSN: 0535-5133 riclinicas@gmail.com Universidad del Zulia Venezuela Mosca, Walter; Navarro, Niurka; Campos, Yelitza; Briceño, Luis Proliferation and bystander suppression induced by antigens of Trypanosoma cruzi.
Evaluation with a modification of the T cell blot technique Investigación Clínica, vol.
47, núm.
3, 2006, pp.
265-282 Universidad del Zulia Maracaibo, Venezuela Available in: http:--www.redalyc.org-articulo.oa?id=372937664006 How to cite Complete issue More information about this article Journals homepage in redalyc.org Scientific Information System Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Non-profit academic project, developed under the open access initiative Invest Clin 47(3): 265 - 282, 2006 Proliferation and bystander suppression induced by antigens of Trypanosoma cruzi. Evaluation with a modification of the T cell blot technique. Walter Mosca, Niurka Navarro, Yelitza Campos and Luis Briceño. Laboratorio de Fisiopatología, Instituto de Biomedicina, Facultad de Medicina, Universidad Central de Venezuela.
Apartado 4043, Caracas 101OA, Venezuela. E-mail: Wmosca@telcel.net.ve Key words: Chagas’ disease, antigens, regulation, cellular immunity. Abstract.
We have studied in vitro proliferation induced by soluble antigenic fractions of T.
cruzi epimastigotes and trypomastigotes, as well as their regulatory effect on the proliferative response to PPD.
Both crude extracts of the parasite as well as bands from Western blots of soluble epimastigotes and trypomastigotes antigens were tested.
Crude extracts elicited higher proliferation in mononuclear cells from patients with chagasic cardiomyopathy (CDM) than in those from patients with no evidence of cardiac pathology (INF).
Fractionated antigens induced a lower proliferative response, in intensity as well as in frequency, than the crude extracts.
With the soluble antigenic fractions of epimastigotes, cells from CDM patients gave ...





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