Green tea halts progression of cardiac transthyretin amyloidosis: an observational reportReport as inadecuate




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Clinical Research in Cardiology

, Volume 101, Issue 10, pp 805–813

First Online: 15 May 2012Received: 08 December 2011Accepted: 19 April 2012

Abstract

BackgroundTreatment options in patients with amyloidotic transthyretin ATTR cardiomyopathy are limited. Epigallocatechin-3-gallate EGCG, the most abundant catechin in green tea GT, inhibits fibril formation from several amyloidogenic proteins in vitro. Thus, it might also halt progression of TTR amyloidosis. This is a single-center observational report on the effects of GT consumption in patients with ATTR cardiomopathy.

Methods19 patients with ATTR cardiomyopathy were evaluated by standard blood tests, echocardiography, and cardiac MRI n = 9 before and after consumption of GT and-or green tea extracts GTE for 12 months.

ResultsFive patients were not followed up for reasons of death n = 2, discontinuation of GT-GTE consumption n = 2, and heart transplantation n = 1. After 12 months no increase of left ventricular LV wall thickness and LV myocardial mass was observed by echocardiography. In the subgroup of patients evaluated by cardiac MRI a mean decrease of LV myocardial mass −12.5 % was detected in all patients. This was accompanied by an increase of mean mitral annular systolic velocity of 9 % in all 14 patients. Total cholesterol 191.9 ± 8.9 vs. 172.7 ± 9.4 mg-dL; p < 0.01 and LDL cholesterol 105.8 ± 7.6 vs. 89.5 ± 8.0 mg-dL; p < 0.01 decreased significantly during the observational period. No serious adverse effects were reported by any of the participants.

ConclusionsOur observation suggests an inhibitory effect of GT and-or GTE on the progression of cardiac amyloidosis. We propose a randomized placebo-controlled investigation to confirm our observation.

KeywordsCardiomyopathy Green tea Transthyretin-derived amyloidosis Epigallocatechin-3-gallate K. Altland, H. A. Katus contributed equally to this work.

Electronic supplementary materialThe online version of this article doi:10.1007-s00392-012-0463-z contains supplementary material, which is available to authorized users.

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Author: Arnt V. Kristen - Stephanie Lehrke - Sebastian Buss - Derliz Mereles - Henning Steen - Philipp Ehlermann - Stefan Hardt -

Source: https://link.springer.com/







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